Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | RECQL | P46063 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 3/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27750307 | 0.78 | TDP1 (0.49) | TDP1KDM4ERECQLMAPTLMNA | |
| SCHEMBL11875188 | 0.77 | SLC6A4 (0.51) | TDP1KDM4ERECQLMAPTLMNA | |
| SCHEMBL11881114 | 0.74 | TDP1 (0.45) | TDP1KDM4ERECQLMAPTLMNA | |
| SCHEMBL10884603 | 0.74 | ADRB2 (0.56) | TDP1KDM4ERECQLMAPTLMNA | |
| SCHEMBL11877952 | 0.71 | ADRB2 (0.63) | TDP1KDM4ERECQLMAPTLMNA | |
| SCHEMBL11881824 | 0.69 | ESR1 (0.45) | TDP1KDM4ERECQLMAPTLMNA | |
| SCHEMBL14597245 | 0.66 | ESR1 (0.57) | TDP1RECQLMAPTLMNABLM | |
| SCHEMBL6644245 | 0.66 | ALDH1A1 (0.59) | TDP1KDM4ERECQLMAPTLMNA | |
| SCHEMBL11880944 | 0.66 | ADRB2 (0.69) | TDP1KDM4EMAPTLMNABLM | |
| SCHEMBL8536213 | 0.65 | APP (0.53) | TDP1KDM4ERECQLMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3943173-A | 3-Alkylamino- alpha-aminomethyl-4-hydroxybenzyl alcohols | SMITHKLINE CORPORATION (US) | 1976-03-09 | — | — | US | claimed |