Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11893691 | 1.00 | KMT2A (0.47) | KMT2AL3MBTL1ALDH1A1MEN1ADORA3 | |
| SCHEMBL15399742 | 0.77 | B3GNT2 (0.34) | KMT2AL3MBTL1 | |
| SCHEMBL25335125 | 0.75 | ALDH1A1 (0.55) | KMT2AL3MBTL1ALDH1A1MEN1ADORA3 | |
| SCHEMBL31160877 | 0.75 | ALDH1A1 (0.55) | KMT2AL3MBTL1ALDH1A1MEN1ADORA3 | |
| SCHEMBL31160981 | 0.75 | ALDH1A1 (0.55) | KMT2AL3MBTL1ALDH1A1MEN1ADORA3 | |
| SCHEMBL1669092 | 0.73 | MAPK10 (0.70) | KMT2AALDH1A1MEN1KDM4EHSD17B10 | |
| SCHEMBL11893787 | 0.73 | MAPK10 (0.70) | KMT2AALDH1A1MEN1KDM4EHSD17B10 | |
| SCHEMBL2600725 | 0.73 | ALDH1A1 (0.73) | KMT2AL3MBTL1ALDH1A1MEN1ADORA3 | |
| SCHEMBL15399747 | 0.72 | DGAT1 (0.41) | — | |
| SCHEMBL15399749 | 0.72 | DGAT1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865704-B2 | Wnt pathway antagonists | SIENA BIOTECH S.P.A. (IT) | 2014-10-21 | — | — | US | disclosed |
| EP-2485728-B1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH SPA (IT) | 2013-07-10 | — | — | EP | disclosed |
| US-20120196851-A1 | WNT PATHWAY ANTAGONISTS | SIENA BIOTECH S.P.A. (IT) | 2012-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196851-A1 | WNT PATHWAY ANTAGONISTS | WNT1, WNT3A, CTNNB1 | KMT2A 4271/4885L3MBTL1 3370/4885ALDH1A1 1797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.