Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 18/20 | 0.49 |
| ▸ | CASP6 | P55212 | 17/20 | 0.49 |
| ▸ | CASP8 | Q14790 | 17/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11911364 | 1.00 | CASP3 (0.49) | CASP3CASP6CASP8CTSD | |
| SCHEMBL2878064 | 1.00 | CASP3 (0.49) | CASP3CASP6CASP8CTSD | |
| SCHEMBL20870231 | 1.00 | CASP3 (0.49) | CASP3CASP6CASP8CTSD | |
| SCHEMBL11896297 | 1.00 | CASP3 (0.49) | CASP3CASP6CASP8CTSD | |
| SCHEMBL2878062 | 1.00 | CASP3 (0.49) | CASP3CASP6CASP8CTSD | |
| SCHEMBL11896298 | 1.00 | CASP3 (0.49) | CASP3CASP6CASP8CTSD | |
| SCHEMBL13260540 | 0.97 | CASP3 (0.47) | CASP3CASP6CASP8CTSD | |
| SCHEMBL17494191 | 0.94 | CASP3 (0.54) | CASP3CASP6CASP8 | |
| SCHEMBL17494192 | 0.94 | CASP3 (0.54) | CASP3CASP6CASP8 | |
| SCHEMBL17494193 | 0.94 | CASP3 (0.54) | CASP3CASP6CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230008495-A1 | NOVEL COMPOUNDS AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | UNIV PARIS (FR) | 2023-01-12 | — | — | US | disclosed |
| US-11407741-B2 | Compounds and their use as selective inhibitors of caspase-2 | Universite De Paris (FR) | 2022-08-09 | — | — | US | disclosed |
| EP-3433243-B1 | NOVEL DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | INST NAT SANTE RECH MED (FR) | 2021-09-08 | — | — | EP | disclosed |
| US-10961219-B2 | Derivatives and their use as selective inhibitors of caspase-2 | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2021-03-30 | — | — | US | disclosed |
| US-20200317647-A1 | NOVEL COMPOUNDS AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | UNIVERSITÉ PARIS CITÉ (FR) | 2020-10-08 | — | — | US | disclosed |
| WO-2019068538-A1 | NOVEL COMPOUNDS AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2019-04-11 | — | — | WO | disclosed |
| US-20190100508-A1 | NOVEL DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | UNIVERSITÉ PARIS CITÉ (FR) | 2019-04-04 | — | — | US | disclosed |
| WO-2017162674-A1 | NOVEL DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2017-09-28 | — | — | WO | disclosed |
| EP-2670774-A1 | CASPASE-2 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012104224-A1 | CASPASE-2 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-08-09 | — | — | WO | disclosed |
| US-20120196892-A1 | NOVEL CASPASE-2 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-08-02 | — | — | US | disclosed |
| US-20080311051-A1 | Caspase-2 Inhibitors And Their Biological Applications | THERAPTOSIS SA (FR) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230008495-A1 | NOVEL COMPOUNDS AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | CASP2, CASP1, CASP5 | CASP3 4/4885CASP6 7/4885CASP8 13/4885 |
| US-20080311051-A1 | Caspase-2 Inhibitors And Their Biological Applications | CASP1, CASP2, CASP9 | CASP3 6/4885CASP6 8/4885CASP8 9/4885 |
| US-20190100508-A1 | NOVEL DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | CASP2, CASP1, CASP5 | CASP3 4/4885CASP6 8/4885CASP8 13/4885 |
| US-20120196892-A1 | NOVEL CASPASE-2 INHIBITORS | CASP2, CASP1, CASP9 | CASP3 5/4885CASP6 8/4885CASP8 13/4885 |
| US-10961219-B2 | Derivatives and their use as selective inhibitors of caspase-2 | CASP2, CASP1, CASP3 | CASP3 3/4885CASP6 8/4885CASP8 13/4885 |
| US-20200317647-A1 | NOVEL COMPOUNDS AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2 | CASP2, CASP1, CASP5 | CASP3 4/4885CASP6 7/4885CASP8 13/4885 |
| US-11407741-B2 | Compounds and their use as selective inhibitors of caspase-2 | CASP2, CASP1, CASP3 | CASP3 3/4885CASP6 7/4885CASP8 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.