Sugi Predict

Sugi Predict / Compounds / SCHEMBL1189663

SCHEMBL1189663

SCHEMBL1189663

CCOC(=O)c1ccc(Cl)cc1N

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 1/20 0.68
▸ ALDH1A1 P00352 9/20 0.60
▸ HSD17B10 Q99714 1/20 0.60
▸ KDM4E B2RXH2 9/20 0.59
▸ RAB9A P51151 2/20 0.58
▸ PKM P14618 1/20 0.58
▸ KMT2A Q03164 2/20 0.57
▸ MEN1 O00255 1/20 0.57
▸ TDP1 Q9NUW8 1/20 0.54
▸ LMNA P02545 2/20 0.53
▸ RXFP1 Q9HBX9 1/20 0.53
▸ HPGD P15428 4/20 0.52
▸ NPSR1 Q6W5P4 1/20 0.52
▸ MAPK1 P28482 1/20 0.51
▸ HTT P42858 1/20 0.51
▸ GAA P10253 2/20 0.50
▸ CA12 O43570 1/20 0.50
▸ CA1 P00915 1/20 0.50
▸ CA2 P00918 1/20 0.50
▸ CA7 P43166 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8134380 0.98 ABL1 (0.66) ABL1ALDH1A1HSD17B10KDM4ERAB9A
SCHEMBL1187950 0.87 ALDH1A1 (0.60) ABL1ALDH1A1HSD17B10KDM4ERAB9A
SCHEMBL21857664 0.85 RAB9A (0.52) ABL1ALDH1A1HSD17B10KDM4ERAB9A
SCHEMBL235046 0.84 TSHR (0.60) ALDH1A1HSD17B10KDM4EKMT2AMAPK1
SCHEMBL522136 0.83 KMT2A (0.59) ALDH1A1KDM4EKMT2ATDP1HPGD
SCHEMBL2132644 0.83 ALDH1A1 (0.64) ABL1ALDH1A1HSD17B10KDM4ERAB9A
SCHEMBL3687067 0.83 ALDH1A1 (0.64) ABL1ALDH1A1HSD17B10KDM4ERAB9A
SCHEMBL29375324 0.83 ALDH1A1 (0.64) ABL1ALDH1A1HSD17B10KDM4ERAB9A
SCHEMBL5248889 0.83 MAPK1 (0.54) ALDH1A1KDM4EKMT2AMAPK1HTT
SCHEMBL9645771 0.82 ALDH1A1 (0.51) ABL1ALDH1A1HSD17B10KDM4ERAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3154982-B1 COMPOUNDS COMPRISING 1,1',2,5'-TETRAHYDROSPIRO[INDOLE-3,2'-PYRROLE]-2,5'-DIONE SYSTEM AS INHIBITORS P53-MDM2 PROTEIN-PROTEIN INTERACTION ADAMED SP ZOO (PL) 2018-05-02 — — EP disclosed
US-20170129903-A1 COMPOUNDS COMPRISING 1,1a,2,5a-TETRAHYDROSPIRO[INDOLE-3,2a-PYRROLE]-2,5a-DIONE SYSTEM AS INHIBITORS P53-MDM2 PROTEIN-PROTEIN INTERACTION ADAMED SP. Z O.O. (PL) 2017-05-11 — — US disclosed
EP-3154982-A1 COMPOUNDS COMPRISING 1,1',2,5'-TETRAHYDROSPIRO[INDOLE-3,2'-PYRROLE]-2,5'-DIONE SYSTEM AS INHIBITORS P53-MDM2 PROTEIN-PROTEIN INTERACTION Adamed sp. z o.o. (PL) 2017-04-19 — — EP disclosed
WO-2015189799-A1 COMPOUNDS COMPRISING 1,1',2,5'-TETRAHYDROSPIRO[INDOLE-3,2'-PYRROLE]-2,5'-DIONE SYSTEM AS INHIBITORS P53-MDM2 PROTEIN-PROTEIN INTERACTION ADAMED SP. Z O.O. (PL) 2015-12-17 — — WO disclosed
US-20110155660-A1 MODIFIED MEMBRANE DOW GLOBAL TECHNOLOGIES LLC 2011-06-30 — — US disclosed
US-7882963-B2 modifying polyamide discriminating layer ( e.g metaphenylene diamine- trimesoyl chloride monomers) with aminoacetophenone or aminothiophenol; fouling resistant surface, improved salt rejection, antimicrobial properties, improved solute, and/or small organics rejection; for water purification DOW GLOBAL TECHNOLOGIES INC. (US) 2011-02-08 — — US disclosed
US-7605265-B2 Heterodimers and methods of using them Biotechnology Research Corporation Ltd. (CN) 2009-10-20 — — US disclosed
US-7605265-B2 Heterodimers and methods of using them Biotechnology Research Corporation Ltd. (CN) 2009-10-20 — — US disclosed
US-20090159527-A1 MODIFIED MEMBRANE DOW GLOBAL TECHNOLOGIES LLC 2009-06-25 — — US disclosed
WO-2008091901-A1 HETERODIMERS AND METHODS OF USING THEM BIOTECHNOLOGY RESEARCH CORPORATION LIMITED (CN) 2008-07-31 — — WO disclosed
EP-0789015-A1 Process for the preparation of N-carboxymethylanthranilic acid esters HOECHST AKTIENGESELLSCHAFT (DE) 1997-08-13 — — EP disclosed
US-5521181-A Bicyclic substituted hexahydrobenz[e]isoindole α-1 adrenergic antagonists ABBOTT LABORATORIES (US) 1996-05-28 — — US disclosed
EP-0459561-B1 Dioxo-tetrahydroquinoline derivatives MERCK SHARP & DOHME (GB) 1995-09-20 — — EP disclosed
EP-0572863-A1 CNS pyrazinoindoles F. HOFFMANN-LA ROCHE AG (CH) 1993-12-08 — — EP disclosed
US-5268378-A Oxo group in 2 and 4 position MERCK SHARP & DOHME, LIMITED (GB) 1993-12-07 — — US disclosed
EP-0459561-A2 Dioxo-tetrahydroquinoline derivatives MERCK SHARP & DOHME LTD. (GB) 1991-12-04 — — EP disclosed
US-5017706-A Colorants for polymers CIBA-GEIGY CORPORATION (US) 1991-05-21 — — US disclosed
US-4307113-A TREATMENT OF DIABETES SANDOZ, INC. (US) 1981-12-22 — — US disclosed
US-4089078-A Arylazopyrazolone dyes for polyester AMERICAN COLOR & CHEMICAL CORPORATION (US) 1978-05-16 — — US disclosed
US-4019857-A Process for the coloration of hydrophobic chemical fibers by metalliferous dyestuffs of cationic character PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1977-04-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170129903-A1 COMPOUNDS COMPRISING 1,1a,2,5a-TETRAHYDROSPIRO[INDOLE-3,2a-PYRROLE]-2,5a-DIONE SYSTEM AS INHIBITORS P53-MDM2 PROTEIN-PROTEIN INTERACTION MDM2, TP53, TP53BP1 ABL1 2607/4885ALDH1A1 596/4885HSD17B10 1678/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.