SCHEMBL522136

SCHEMBL522136

CCOC(=O)c1ccc(Cl)cc1Cl

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.59
KDM4E B2RXH2 1/20 0.57
MAPT P10636 1/20 0.56
ALOX15 P16050 2/20 0.55
HPGD P15428 1/20 0.54
CYP4F2 P78329 1/20 0.54
CYP4A11 Q02928 1/20 0.54
BAZ2B Q9UIF8 1/20 0.54
BAZ2A Q9UIF9 1/20 0.54
MAPK1 P28482 2/20 0.54
TDP1 Q9NUW8 3/20 0.53
TSHR P16473 2/20 0.53
CASP1 P29466 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
ALDH1A1 P00352 1/20 0.53
HIF1A Q16665 1/20 0.53
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA7 P43166 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL235046 0.87 TSHR (0.60) KMT2AKDM4EMAPTALOX15CYP4F2
SCHEMBL7520602 0.86 KMT2A (0.68) KMT2AKDM4EMAPTHPGDMAPK1
SCHEMBL11225504 0.86 CYP4F2 (0.67) KMT2AKDM4EMAPTALOX15HPGD
SCHEMBL9827284 0.86 BAZ2B (0.58) KDM4EALOX15HPGDCYP4F2CYP4A11
SCHEMBL5248889 0.86 MAPK1 (0.54) KMT2AKDM4EALOX15CYP4F2CYP4A11
SCHEMBL10413526 0.85 SMN1; SMN2 (0.57) KMT2AKDM4EMAPTHPGDMAPK1
SCHEMBL3304119 0.84 CA12 (0.70) KMT2AKDM4EMAPTALOX15HPGD
SCHEMBL10487630 0.84 MAPK1 (0.52) KMT2AKDM4EALOX15CYP4F2CYP4A11
SCHEMBL3751812 0.84 CYP4F2 (0.53) KMT2AKDM4ECYP4F2CYP4A11BAZ2B
SCHEMBL1760466 0.84 CA12 (0.57) CYP4F2CYP4A11BAZ2BBAZ2ATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113387790-B Preparation method of chloroalkoxy-1, 3-diphenyl-beta-diketone 佛山华铕光电材料股份有限公司 2022-08-05 CN disclosed
CN-113387790-A Preparation method of chloroalkoxy-1, 3-diphenyl-beta-diketone 佛山华铕光电材料股份有限公司 2021-09-14 CN disclosed
WO-2018057219-A1 METHOD OF ALLOCATING INDIVIDUAL OIL OR WATER PRODUCTION CONTRIBUTIONS FROM MULTIPLE COMBINED SOURCES SPECTRUM TRACER SERVICES, LLC (US) 2018-03-29 WO disclosed
US-20180080314-A1 METHOD OF ALLOCATING INDIVIDUAL OIL OR WATER PRODUCTION CONTRIBUTIONS FROM MULTIPLE COMBINED SOURCES SPECTRUM TRACER SERVICES, LLC 2018-03-22 US disclosed
US-20130150611-A1 PROCESS FOR PRODUCING CARBOXYLIC ACID ESTER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-06-13 US disclosed
WO-2012176930-A1 PROCESS FOR PRODUCING CARBOXYLIC ACID ESTER SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-12-27 WO disclosed
EP-2415741-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND Sumitomo Chemical Company, Limited (JP) 2012-02-08 EP disclosed
US-20120029195-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND AND CATALYST THEREFOR SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-02-02 US disclosed
US-20120010417-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-01-12 US disclosed
EP-1521749-B8 PHENYL-(4-(3-PHENYL-1H-PYRAZOL-4-YL)-PYRIMIDIN-2-Yl)-AMINE DERIVATIVES NOVARTIS AG (CH) 2010-12-22 EP disclosed
US-4782156-A Nitriles of halogenated quinolonecarboxylic acids BAYER AKTIENGESELLSCHAFT (DE) 1988-11-01 US disclosed
US-4680401-A Preparation of halogenated quinolonecarboxylic acids BAYER AKTIENGESELLSCHAFT (DE) 1987-07-14 US disclosed
US-4605656-A Pyridine and pyrazine oxime compounds as fungicides HOFFMANN-LA ROCHE INC. (US) 1986-08-12 US disclosed
EP-0135252-A2 Process for preparing 3-substituted-3-aminonitrile ELI LILLY AND COMPANY (US) 1985-03-27 EP disclosed
EP-0129407-A2 Improvements in and relating to (3-aryl-5-isothiazolyl)ureas ELI LILLY AND COMPANY (US) 1984-12-27 EP disclosed
US-4356295-A COORDINATION CATALYSTS MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) 1982-10-26 US disclosed
US-4140859-A Dilithiated 2-(o-tolyl)-2-imidazolines SANDOZ, INC. (US) 1979-02-20 US disclosed
US-4122200-A 6',2-(2'Arylchromonyl) propionic acids, and analgesic and anti-inflammatory derivatives thereof LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1978-10-24 US disclosed
US-4101553-A Imidazo[2,1-a]isoquinolines SANDOZ, INC. (US) 1978-07-18 US disclosed
US-4097582-A 6',2-(2'-Arylchromonyl) propionic acids, and analgesic and anti-inflammatory derivatives thereof LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1978-06-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010417-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND ADH1A, ADH1C, ADH5 KMT2A 1923/4885KDM4E 2660/4885MAPT 1818/4885
US-20130150611-A1 PROCESS FOR PRODUCING CARBOXYLIC ACID ESTER ADH5, ADH1A, ADH1C KMT2A 1065/4885KDM4E 620/4885MAPT 4621/4885
US-20120029195-A1 METHOD FOR PRODUCING ALCOHOL COMPOUND AND CATALYST THEREFOR ADH1A, ADH1C, ADH5 KMT2A 1971/4885KDM4E 1708/4885MAPT 2830/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.