Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.62 |
| ▸ | SCD5 | Q86SK9 | 11/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | CDH1 | P12830 | 1/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.54 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.54 |
| ▸ | SCD | O00767 | 5/20 | 0.53 |
| ▸ | RARA | P10276 | 1/20 | 0.51 |
| ▸ | RARB | P10826 | 1/20 | 0.51 |
| ▸ | RARG | P13631 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4089293 | 0.93 | ALDH1A1 (0.59) | ALDH1A1PTPN1SCD5MAPTHPGD | |
| SCHEMBL4020118 | 0.82 | ALDH1A1 (0.60) | ALDH1A1PTPN1SCD5MAPTHPGD | |
| SCHEMBL72786 | 0.78 | ALDH1A1 (1.00) | ALDH1A1PTPN1MAPTHPGDRECQL | |
| SCHEMBL71299 | 0.78 | ALDH1A1 (1.00) | ALDH1A1PTPN1MAPTHPGDRECQL | |
| SCHEMBL3227675 | 0.77 | PTPN1 (1.00) | ALDH1A1PTPN1MAPTHPGDRECQL | |
| SCHEMBL892967 | 0.77 | CDH1 (0.82) | ALDH1A1PTPN1MAPTHPGDRECQL | |
| SCHEMBL1178695 | 0.77 | ALDH1A1 (0.72) | ALDH1A1PTPN1MAPTHPGDRECQL | |
| SCHEMBL892878 | 0.77 | ALDH1A1 (0.72) | ALDH1A1PTPN1MAPTHPGDRECQL | |
| SCHEMBL72428 | 0.77 | ALDH1A1 (0.72) | ALDH1A1PTPN1MAPTHPGDRECQL | |
| SCHEMBL11902221 | 0.76 | ALDH1A1 (0.66) | ALDH1A1PTPN1SCD5MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120202794-A1 | COMPOUNDS | PHARMASSET, INC. (US) | 2012-08-09 | — | — | US | disclosed |
| WO-2012103113-A1 | PYRAZINE AND IMIDAZOLIDINE DERIVATIVES AND THEIR USES TO TREAT HEPATITIS C | GILEAD PHARMASSET, LLC (US) | 2012-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120202794-A1 | COMPOUNDS | HAVCR2, MAVS, GOT2 | ALDH1A1 253/4885PTPN1 3220/4885SCD5 1677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.