Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903588 | 0.84 | GPR88 (0.44) | GPR88PARP10SMN1; SMN2 | |
| SCHEMBL15121674 | 0.79 | GPR88 (0.50) | GPR88HIF1AMAPK1ADRA2AADRA1A | |
| SCHEMBL11903612 | 0.76 | FFAR1 (0.43) | GPR88PARP10LMNAFFAR1ADRA1A | |
| SCHEMBL6873511 | 0.73 | GPR88 (0.57) | GPR88HIF1ALMNAMAPK1FFAR1 | |
| SCHEMBL1554247 | 0.72 | GPR88 (0.60) | GPR88HIF1ALMNAMAPK1TAS1R3 | |
| SCHEMBL6686922 | 0.71 | ALDH1A1 (0.61) | GPR88MAPK1KDM4ECYP1A2 | |
| SCHEMBL4860223 | 0.69 | CA1 (0.50) | LMNAKDM4ECYP1A2SMN1; SMN2 | |
| SCHEMBL27546842 | 0.69 | GPR88 (0.47) | GPR88HIF1AFFAR1SMN1; SMN2 | |
| SCHEMBL27567026 | 0.68 | GPR88 (0.43) | GPR88HIF1AFFAR1KDM4ESMN1; SMN2 | |
| SCHEMBL12436446 | 0.68 | PPARG (0.50) | GPR88HIF1ALMNAMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |