Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY6 | Q15077 | 2/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | RUNX1 | Q01196 | 6/20 | 0.47 |
| ▸ | CBFB | Q13951 | 3/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903471 | 0.90 | P2RY6 (0.67) | P2RY6ALOX5EPHX2RUNX1CBFB | |
| SCHEMBL3340524 | 0.83 | ALDH1A1 (0.58) | P2RY6ALOX5EPHX2RUNX1CHEK1 | |
| SCHEMBL5683368 | 0.80 | P2RY6 (0.54) | P2RY6ALOX5EPHX2CBFBCHEK1 | |
| SCHEMBL11903477 | 0.79 | TRPV1 (0.57) | RUNX1CBFBTRPV1ALDH1A1RAB9A | |
| SCHEMBL4239794 | 0.75 | ALOX5 (0.78) | P2RY6ALOX5EPHX2CHEK1LIMK1 | |
| SCHEMBL11903487 | 0.75 | CYP1A2 (0.54) | RUNX1TRPV1ALDH1A1RAB9AKDM4E | |
| SCHEMBL11903464 | 0.75 | TRPV1 (0.60) | RUNX1CBFBTRPV1ALDH1A1RAB9A | |
| SCHEMBL179143 | 0.74 | CBFB (0.81) | RUNX1CBFBRAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL11903459 | 0.74 | KDM4E (0.56) | RUNX1CBFBTRPV1ALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL2247414 | 0.74 | ALOX5 (0.76) | P2RY6ALOX5EPHX2CHEK1LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | claimed |
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |