Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY6 | Q15077 | 2/20 | 0.67 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.60 |
| ▸ | RUNX1 | Q01196 | 7/20 | 0.59 |
| ▸ | CBFB | Q13951 | 3/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903475 | 0.90 | P2RY6 (0.56) | P2RY6ALOX5EPHX2RUNX1CBFB | |
| SCHEMBL11903481 | 0.79 | TRPV1 (0.72) | RUNX1CBFBTRPV1ALDH1A1RAB9A | |
| SCHEMBL8603371 | 0.78 | ALOX5 (0.73) | P2RY6ALOX5EPHX2CHEK1LIMK1 | |
| SCHEMBL12082439 | 0.75 | ALOX5 (0.69) | ALOX5EPHX2CBFBCHEK1LIMK1 | |
| SCHEMBL10758216 | 0.75 | ALOX5 (1.00) | ALOX5EPHX2CHEK1LIMK1CDK5 | |
| SCHEMBL11903492 | 0.75 | NPC1 (0.66) | RUNX1CBFBTRPV1ALDH1A1RAB9A | |
| SCHEMBL11903468 | 0.75 | TRPV1 (0.74) | RUNX1CBFBTRPV1ALDH1A1RAB9A | |
| SCHEMBL11903462 | 0.74 | ALDH1A1 (0.60) | P2RY6RUNX1CBFBTRPV1ALDH1A1 | |
| SCHEMBL11903652 | 0.74 | TRPV1 (0.77) | RUNX1CBFBTRPV1ALDH1A1RAB9A | |
| SCHEMBL11903498 | 0.74 | TRPV1 (0.77) | RUNX1CBFBTRPV1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | claimed |
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |