Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.57 |
| ▸ | RUNX1 | Q01196 | 7/20 | 0.54 |
| ▸ | CBFB | Q13951 | 3/20 | 0.54 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.46 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903462 | 0.80 | ALDH1A1 (0.60) | TRPV1RUNX1CBFBSCN10AP2RY6 | |
| SCHEMBL11903498 | 0.80 | TRPV1 (0.77) | TRPV1RUNX1CBFBCHEK2NPBWR1 | |
| SCHEMBL10146526 | 0.76 | TRPV1 (0.59) | TRPV1RUNX1CBFBSCN10APDE10A | |
| SCHEMBL11903652 | 0.74 | TRPV1 (0.77) | TRPV1RUNX1CBFBCHEK2NPBWR1 | |
| SCHEMBL11903481 | 0.74 | TRPV1 (0.72) | TRPV1RUNX1CBFBCHEK2CYP1A2 | |
| SCHEMBL902354 | 0.73 | CBFB (0.64) | TRPV1RUNX1CBFBSCN10AP2RY6 | |
| SCHEMBL11903468 | 0.73 | TRPV1 (0.74) | TRPV1RUNX1CBFBBACE1CHEK2 | |
| SCHEMBL11903447 | 0.72 | TRPV1 (0.73) | TRPV1RUNX1CBFBCHEK2CYP3A4 | |
| SCHEMBL11903519 | 0.72 | TRPV1 (0.72) | TRPV1RUNX1CBFBSCN10ACHEK2 | |
| SCHEMBL14475012 | 0.71 | TRPV1 (0.54) | TRPV1RUNX1CBFBSCN10AP2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293780-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | U.S. DEPARTMENT OF ENERGY (US) | 2012-10-23 | — | — | US | disclosed |
| US-8242284-B1 | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE UNITED STATES DEPARTMENT OF ENERGY (US) | 2012-08-14 | — | — | US | disclosed |