Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 3/20 | 0.64 |
| ▸ | RUNX1 | Q01196 | 10/20 | 0.63 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.57 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.52 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29377925 | 0.78 | CBFB (0.84) | CBFBRUNX1TRPV1DGAT1P2RY6 | |
| SCHEMBL11903498 | 0.77 | TRPV1 (0.77) | CBFBRUNX1TRPV1NPC1RAB9A | |
| SCHEMBL902859 | 0.77 | ADORA3 (0.63) | CBFBDGAT1P2RY6BACE1NPC1 | |
| SCHEMBL11903481 | 0.77 | TRPV1 (0.72) | CBFBRUNX1TRPV1DGAT1NPC1 | |
| SCHEMBL10146526 | 0.76 | TRPV1 (0.59) | CBFBRUNX1TRPV1SCN10APDE10A | |
| SCHEMBL11903652 | 0.74 | TRPV1 (0.77) | CBFBRUNX1TRPV1NPC1RAB9A | |
| SCHEMBL13286844 | 0.74 | NPC1 (0.57) | CBFBPDE10ANPC1RAB9A | |
| SCHEMBL903006 | 0.73 | METAP2 (0.61) | CBFBDGAT1NPC1RAB9A | |
| SCHEMBL16121415 | 0.73 | TRPV1 (0.63) | CBFBRUNX1TRPV1DGAT1BACE1 | |
| SCHEMBL11903539 | 0.73 | TRPV1 (0.57) | CBFBRUNX1TRPV1P2RY6BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |