Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15121635 | 0.84 | CYP1A2 (0.39) | APPLMNACYP1A2FFAR1PARP10 | |
| SCHEMBL15121577 | 0.83 | FFAR1 (0.40) | APPLMNACYP1A2FFAR1GAA | |
| SCHEMBL11903579 | 0.76 | GPR88 (0.39) | LMNACYP1A2FFAR1GAAHTT | |
| SCHEMBL15798252 | 0.75 | MAPK1 (0.51) | — | |
| SCHEMBL6685868 | 0.73 | ALDH1A1 (0.53) | APPLMNA | |
| SCHEMBL11903483 | 0.72 | LMNA (0.41) | LMNACYP1A2FFAR1PARP10GAA | |
| SCHEMBL11903585 | 0.71 | KCNH2 (0.41) | PARP10 | |
| SCHEMBL11903445 | 0.69 | GPR88 (0.37) | APPLMNACYP1A2 | |
| SCHEMBL11903558 | 0.68 | KMT2A (0.44) | LMNAPARP10HTT | |
| SCHEMBL11903612 | 0.67 | FFAR1 (0.43) | LMNACYP1A2FFAR1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497271-B2 | Modulators of G protein-coupled receptor 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-07-30 | — | — | US | disclosed |
| EP-2486030-B1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL MYERS SQUIBB CO (US) | 2013-07-24 | — | — | EP | disclosed |
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |