Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 8/20 | 0.34 |
| ▸ | ATR | Q13535 | 4/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11903445 | 0.82 | GPR88 (0.37) | KCNH2KDM4EGPR88THRATHRB | |
| SCHEMBL15798122 | 0.77 | PARP1 (0.40) | SIRT2KDM4EPARP10 | |
| SCHEMBL12497540 | 0.77 | GRM2 (0.41) | KDM4EATMKDR | |
| SCHEMBL15797861 | 0.73 | CHEK1 (0.41) | KDM4E | |
| SCHEMBL11903608 | 0.71 | APP (0.40) | PARP10 | |
| SCHEMBL10002426 | 0.70 | ESR1 (0.40) | KDM4E | |
| SCHEMBL29053404 | 0.69 | THRA (0.49) | KDM4ETHRATHRB | |
| SCHEMBL15134973 | 0.68 | DGAT1 (0.47) | KDM4E | |
| SCHEMBL11904813 | 0.68 | GPR88 (0.37) | KDM4EGPR88 | |
| SCHEMBL15121608 | 0.68 | GPR88 (0.37) | KDM4EGPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497271-B2 | Modulators of G protein-coupled receptor 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-07-30 | — | — | US | disclosed |
| EP-2486030-B1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL MYERS SQUIBB CO (US) | 2013-07-24 | — | — | EP | disclosed |
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |