Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15121577 | 0.89 | FFAR1 (0.40) | LMNATDP1CYP1A2ADRB2ADRB1 | |
| SCHEMBL15121643 | 0.80 | KMT2A (0.39) | LMNATDP1CYP1A2ADRB2ADRB1 | |
| SCHEMBL15121906 | 0.78 | KMT2A (0.45) | TDP1FFAR1GAAALDH1A1POLB | |
| SCHEMBL11903579 | 0.75 | GPR88 (0.39) | LMNATDP1CYP1A2ADRB2ADRB1 | |
| SCHEMBL11903608 | 0.72 | APP (0.40) | LMNACYP1A2FFAR1GAAHTT | |
| SCHEMBL11904813 | 0.72 | GPR88 (0.37) | LMNATDP1CYP1A2ADRB2ADRB1 | |
| SCHEMBL15121608 | 0.72 | GPR88 (0.37) | LMNATDP1CYP1A2ADRB2ADRB1 | |
| SCHEMBL2556114 | 0.70 | ALDH1A1 (0.48) | LMNATDP1ADRB2ADRB1CNR1 | |
| SCHEMBL15335388 | 0.69 | ALDH1A3 (0.50) | LMNATDP1KDM4ECYP3A4TSHR | |
| SCHEMBL5228349 | 0.69 | ITGB3 (0.53) | LMNATDP1CYP1A2ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8497271-B2 | Modulators of G protein-coupled receptor 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-07-30 | — | — | US | disclosed |
| EP-2486030-B1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL MYERS SQUIBB CO (US) | 2013-07-24 | — | — | EP | disclosed |
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |