Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 7/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1141677 | 0.89 | JAK2 (0.43) | JAK2PDPK1JAK3NTRK1MKNK1 | |
| Hydrochloric Acid SCHEMBL1141713 | 0.88 | JAK2 (0.43) | JAK2PDPK1JAK3NTRK1MKNK1 | |
| SCHEMBL13552135 | 0.79 | KIF11 (0.42) | KIF11JAK2GSK3BPDPK1ALDH1A1 | |
| SCHEMBL12907189 | 0.79 | JAK2 (0.66) | JAK2PDPK1ALDH1A1MITFTP53 | |
| SCHEMBL22339348 | 0.79 | JAK2 (0.51) | KIF11JAK2GSK3BPDPK1ALDH1A1 | |
| SCHEMBL3781571 | 0.79 | JAK2 (0.46) | JAK2GSK3BJAK3NTRK1PRKAG1 | |
| SCHEMBL11911446 | 0.74 | JAK2 (0.42) | KIF11JAK2GSK3BPDPK1ALDH1A1 | |
| SCHEMBL11911448 | 0.74 | GSK3B (0.47) | KIF11JAK2GSK3BPDPK1ALDH1A1 | |
| SCHEMBL14818880 | 0.73 | MAP2K4 (0.49) | ALDH1A1NTRK1KDM4EMAPTMAPK1 | |
| SCHEMBL11911444 | 0.73 | PRKAG1 (0.67) | JAK2GSK3BJAK3PRKAG1PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8232308-B2 | Methods for treating a disease in which Rho kinase is involved | UBE INDUSTRIES, LTD. (JP) | 2012-07-31 | — | — | US | disclosed |
| US-20110039891-A1 | Methods for treating a disease in which Rho kinase is involved | UBE INDUSTRIES, LTD. (JP) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039891-A1 | Methods for treating a disease in which Rho kinase is involved | RHOA, ROCK1, ROCK2 | KIF11 1302/4885JAK2 317/4885GSK3B 1341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.