Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | PRKACA | P17612 | 2/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.49 |
| ▸ | MARK3 | P27448 | 2/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.49 |
| ▸ | CLK2 | P49760 | 2/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.49 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.49 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.49 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12934038 | 0.79 | DYRK3 (0.50) | DYRK3PRKD3MAP4K4PRKACARPS6KB1 | |
| SCHEMBL22430490 | 0.79 | DYRK3 (0.50) | DYRK3PRKD3MAP4K4PRKACARPS6KB1 | |
| SCHEMBL16790649 | 0.78 | DYRK3 (0.49) | DYRK3PRKD3MAP4K4PRKACARPS6KB1 | |
| SCHEMBL11927547 | 0.78 | ADK (0.31) | DYRK3PRKD3MAP4K4PRKACARPS6KB1 | |
| SCHEMBL1585102 | 0.78 | ADK (0.49) | DYRK3PRKD3MAP4K4PRKACARPS6KB1 | |
| SCHEMBL400627 | 0.75 | DYRK3 (0.44) | DYRK3PRKD3MAP4K4PRKACARPS6KB1 | |
| SCHEMBL1783992 | 0.74 | PIK3CD (0.51) | DYRK3PRKD3MAP4K4PRKACARPS6KB1 | |
| SCHEMBL29503447 | 0.74 | DYRK3 (0.59) | DYRK3PRKD3MAP4K4PRKACARPS6KB1 | |
| SCHEMBL3782622 | 0.74 | DYRK3 (0.59) | DYRK3PRKD3MAP4K4PRKACARPS6KB1 | |
| SCHEMBL19304152 | 0.74 | SRC (0.57) | DYRK3PRKD3MAP4K4PRKACARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120208819-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208819-A1 | HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS | PDK1, PDK2, PDK3 | DYRK3 2236/4885PRKD3 23/4885MAP4K4 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.