Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.96 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CES2 | O00748 | 4/20 | 0.54 |
| ▸ | CES1 | P23141 | 4/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.50 |
| ▸ | PPARG | P37231 | 7/20 | 0.50 |
| ▸ | PPARD | Q03181 | 7/20 | 0.50 |
| ▸ | PPARA | Q07869 | 7/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TLR2 | O60603 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | FABP4 | P15090 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5474445 | 0.98 | HAO1 (1.00) | HAO1KMT2AMAPTCES2CES1 | |
| SCHEMBL2528845 | 0.98 | HAO1 (1.00) | HAO1KMT2AMAPTCES2CES1 | |
| SCHEMBL5468904 | 0.98 | HAO1 (1.00) | HAO1KMT2AMAPTCES2CES1 | |
| SCHEMBL8741845 | 0.98 | HAO1 (1.00) | HAO1KMT2AMAPTCES2CES1 | |
| SCHEMBL8074587 | 0.98 | HAO1 (1.00) | HAO1KMT2AMAPTCES2CES1 | |
| SCHEMBL285014 | 0.93 | HAO1 (0.83) | HAO1KMT2AMAPTCES2CES1 | |
| SCHEMBL7796552 | 0.91 | HAO1 (0.80) | HAO1KMT2AMAPTCES2CES1 | |
| SCHEMBL18010753 | 0.86 | HAO1 (0.79) | HAO1KMT2AMAPTCES2CES1 | |
| SCHEMBL247453 | 0.83 | HAO1 (0.68) | HAO1CES2CES1AKR1B1TSHR | |
| SCHEMBL250549 | 0.83 | HAO1 (0.67) | HAO1KMT2AMAPTCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110114351-A | The heterocycle inhibitor of MCT4 | 维托尔股份有限公司 | 2019-08-09 | — | — | CN | disclosed |
| EP-2509949-B1 | PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS | UNIV GEORGIA (US) | 2014-04-23 | — | — | EP | disclosed |
| US-8703801-B2 | Pyridinone hydroxycyclopentyl carboxamides: HIV integrase inhibitors with therapeutic applications | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2014-04-22 | — | — | US | disclosed |
| US-20120282218-A1 | PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC. (US) | 2012-11-08 | — | — | US | disclosed |
| EP-2509949-A2 | PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS | University Of Georgia Research Foundation, Inc. (US) | 2012-10-17 | — | — | EP | disclosed |
| US-8071285-B1 | Zinc finger protein derivatives and methods of using same | LAWYER CARL HENRY (US) | 2011-12-06 | — | — | US | disclosed |
| WO-2011071849-A2 | PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2011-06-16 | — | — | WO | disclosed |
| US-7888375-B2 | Pyridinone diketo acids: inhibitors of HIV replication | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC (US) | 2011-02-15 | — | — | US | disclosed |
| US-20100092427-A1 | Pyridinone Diketo Acids: Inhibitors of HIV Replication in Combination Therapy | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION (US) | 2010-04-15 | — | — | US | disclosed |
| US-7569573-B2 | Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase | THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2009-08-04 | — | — | US | disclosed |
| CN-1244610-C | Cyanate ester based thermoset compositions | GEN ELECTRIC (US) | 2006-03-08 | — | — | CN | disclosed |
| EP-1620120-A2 | LONG ACTING BIOLOGICALLY ACTIVE CONJUGATES | Sequoia Pharmaceuticals (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2004085505-A2 | LONG ACTING BIOLOGICALLY ACTIVE CONJUGATES | SEQUOIA PHARMACEUTICALS, INC. (US) | 2004-10-07 | — | — | WO | disclosed |
| CN-1229817-A | Cyanate ester based thermoset compositions | GEN ELECTRIC (US) | 1999-09-29 | — | — | CN | disclosed |
| EP-0454843-A4 | METHOD AND APPARATUS FOR THE RAPID DEPOSITION BY CHEMICAL VAPOR DEPOSITION WITH LOW VAPOR PRESSURE REACTANTS | GEORGIA TECH RES INST (US) | 1994-12-28 | — | — | EP | disclosed |
| EP-0293220-B1 | Pharmacologically active 2-and 3-substituted (1', 5'-diaryl-3-pyrazolyl)-N-Hydroxypropanamides and method for synthesizing | ORTHO PHARMA CORP (US) | 1994-08-31 | — | — | EP | disclosed |
| EP-0454843-A1 | METHOD AND APPARATUS FOR THE RAPID DEPOSITION BY CHEMICAL VAPOR DEPOSITION WITH LOW VAPOR PRESSURE REACTANTS | GEORGIA TECH RESEARCH CORPORATION (US) | 1991-11-06 | — | — | EP | disclosed |
| US-5051518-A | Antiinflammatory agents and cardiovascular disorders | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-09-24 | — | — | US | disclosed |
| WO-1991007236-A1 | METHOD AND APPARATUS FOR THE RAPID DEPOSITION BY CHEMICAL VAPOR DEPOSITION WITH LOW VAPOR PRESSURE REACTANTS | GEORGIA TECH RESEARCH CORPORATION (US) | 1991-05-30 | — | — | WO | disclosed |
| EP-0293220-A2 | Pharmacologically active 2-and 3-substituted (1', 5'-diaryl-3-pyrazolyl)-N-Hydroxypropanamides and method for synthesizing | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-11-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100092427-A1 | Pyridinone Diketo Acids: Inhibitors of HIV Replication in Combination Therapy | TKT, DHFR, DTYMK | HAO1 360/4885KMT2A 2141/4885MAPT 134/4885 |
| US-20120282218-A1 | PYRIDINONE HYDROXYCYCLOPENTYL CARBOXAMIDES: HIV INTEGRASE INHIBITORS WITH THERAPEUTIC APPLICATIONS | PAICS, DUT, AADAC | HAO1 1207/4885KMT2A 2438/4885MAPT 585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.