Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.72 |
| ▸ | HTR2A | P28223 | 2/20 | 0.65 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.65 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 5/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HTR1B | P28222 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR1E | P28566 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22122400 | 0.88 | CHRNB2 (0.60) | CSNK2A1HTR2ATRPM8GPR84SLC6A4 | |
| SCHEMBL5430044 | 0.85 | HTR2A (0.80) | CSNK2A1HTR2ATRPM8GPR84SLC6A4 | |
| SCHEMBL2005588 | 0.84 | CSNK2A1 (1.00) | CSNK2A1HTR2ATRPM8GPR84SLC6A4 | |
| SCHEMBL6640808 | 0.80 | HTR2A (0.73) | CSNK2A1HTR2ATRPM8GPR84SLC6A4 | |
| SCHEMBL29791683 | 0.79 | HTR2A (1.00) | CSNK2A1HTR2ATRPM8GPR84SLC6A4 | |
| SCHEMBL29444443 | 0.79 | HTR2A (0.71) | CSNK2A1HTR2ATRPM8GPR84SLC6A4 | |
| SCHEMBL13715518 | 0.79 | HTR2A (0.71) | CSNK2A1HTR2ATRPM8GPR84SLC6A4 | |
| SCHEMBL28116971 | 0.79 | HTR2A (0.71) | CSNK2A1HTR2ATRPM8GPR84SLC6A4 | |
| SCHEMBL1520598 | 0.79 | HTR2A (1.00) | CSNK2A1HTR2ATRPM8GPR84SLC6A4 | |
| SCHEMBL733712 | 0.79 | HTR2A (0.71) | CSNK2A1HTR2ATRPM8GPR84SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8742100-B2 | Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-06-03 | — | — | US | disclosed |
| US-8742100-B2 | Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-06-03 | — | — | US | disclosed |
| US-20120197014-A1 | SMALL MOLECULE INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE WITH POTENTIAL ANTICANCER ACTIVITY | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2012-08-02 | — | — | US | disclosed |
| US-20120197014-A1 | SMALL MOLECULE INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE WITH POTENTIAL ANTICANCER ACTIVITY | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2012-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120197014-A1 | SMALL MOLECULE INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE WITH POTENTIAL ANTICANCER ACTIVITY | ICMT, BHMT, SHMT1 | CSNK2A1 929/4885HTR2A 4607/4885TRPM8 4388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.