SCHEMBL11962385

SCHEMBL11962385

O=P(c1ccccc1)(c1ccccc1)c1ccc(-c2ccc3ccc4ncccc4c3n2)cc1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.48
CYP3A4 P08684 1/20 0.42
KDM4E B2RXH2 1/20 0.38
MAPT P10636 1/20 0.38
MAPK14 Q16539 1/20 0.37
TRPV1 Q8NER1 1/20 0.37
TOP1 P11387 3/20 0.35
PABPC1 P11940 1/20 0.35
DHODH Q02127 2/20 0.35
MET P08581 1/20 0.35
PDE10A Q9Y233 1/20 0.35
NPC1 O15118 1/20 0.35
PARP1 P09874 1/20 0.35
KCNA5 P22460 2/20 0.34
KCNN4 O15554 1/20 0.34
CYP1A1 P04798 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP1B1 Q16678 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL669488 0.85 LMNA (0.61) LMNACYP3A4KDM4EMAPTTOP1
SCHEMBL17403770 0.84 MMP2 (0.46) LMNACYP3A4KDM4EMAPTTRPV1
SCHEMBL11962386 0.84 PARP1 (0.42) LMNACYP3A4KDM4EMAPTTOP1
SCHEMBL11962387 0.84 PARP1 (0.42) LMNACYP3A4KDM4EMAPTTOP1
SCHEMBL27820373 0.82 LMNA (0.57) LMNACYP3A4KDM4EMAPTTOP1
SCHEMBL17403771 0.82 TOP1 (0.37) LMNAKDM4EMAPTTOP1DHODH
Pyrazine SCHEMBL28948452 0.81 LMNA (0.56) LMNACYP3A4KDM4EMAPTTOP1
SCHEMBL17403775 0.80 PARP1 (0.46) LMNAKDM4EMAPTTOP1NPC1
SCHEMBL14278920 0.79 LMNA (0.50) LMNACYP3A4KDM4EMAPTTRPV1
SCHEMBL29120745 0.79 LMNA (0.50) LMNACYP3A4KDM4EMAPTTRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9054319-B2 Organic electroluminescence device IDEMITSU KOSAN CO., LTD. (JP) 2015-06-09 US disclosed
US-9054319-B2 Organic electroluminescence device IDEMITSU KOSAN CO., LTD. (JP) 2015-06-09 US disclosed
US-8759819-B2 Organic electroluminescence device IDEMITSU KOSAN CO., LTD. (JP) 2014-06-24 US disclosed
US-8759819-B2 Organic electroluminescence device IDEMITSU KOSAN CO., LTD. (JP) 2014-06-24 US disclosed
US-20140131680-A1 ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2014-05-15 US disclosed
US-20140131680-A1 ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. (JP) 2014-05-15 US disclosed
US-20120199817-A1 ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. 2012-08-09 US disclosed
US-20120199817-A1 ORGANIC ELECTROLUMINESCENCE DEVICE IDEMITSU KOSAN CO., LTD. 2012-08-09 US disclosed
US-20100283043-A1 ORGANIC EL ELEMENT IDEMITSU LOSAN CO., LTD. 2010-11-11 US disclosed
US-20100283043-A1 ORGANIC EL ELEMENT IDEMITSU LOSAN CO., LTD. 2010-11-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120199817-A1 ORGANIC ELECTROLUMINESCENCE DEVICE FTO, EML4, SLC43A1 LMNA 2185/4885CYP3A4 3523/4885KDM4E 1749/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.