Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 7/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL136449 | 0.87 | NR1H4 (0.51) | NR1H4PRMT5LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL11965262 | 0.86 | MAOB (0.54) | MEN1KMT2ALTB4RLTB4R2MAOB | |
| SCHEMBL135160 | 0.84 | PRMT5 (0.48) | NR1H4PRMT5LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL20394187 | 0.83 | ALOX5 (0.54) | LMNAL3MBTL1MEN1KMT2AMAOB | |
| SCHEMBL1008116 | 0.82 | LTB4R (0.61) | NR1H4LMNAL3MBTL1ALDH1A1LTB4R | |
| SCHEMBL1203178 | 0.82 | ALOX5 (0.67) | NR1H4PRMT5LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL4089117 | 0.81 | PRMT5 (0.50) | NR1H4PRMT5LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL14572101 | 0.81 | L3MBTL1 (0.53) | NR1H4PRMT5LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL4852083 | 0.81 | MEN1 (0.56) | NR1H4PRMT5LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL23117661 | 0.80 | CASP3 (0.52) | PRMT5L3MBTL1MEN1KMT2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242145-B2 | Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors | PANMIRA PHARMACEUTICALS, LLC (US) | 2012-08-14 | — | — | US | disclosed |
| US-20110098302-A1 | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098302-A1 | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | PTGDR, PTGDR2, PTGER1 | NR1H4 190/4885PRMT5 4395/4885LMNA 2386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.