SCHEMBL119714

SCHEMBL119714

Fc1cc(CBr)ccc1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 1/20 0.42
CYP4A11 Q02928 1/20 0.42
MAPT P10636 1/20 0.41
MAPK1 P28482 1/20 0.41
GRM2 Q14416 2/20 0.41
PNMT P11086 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
IDO1 P14902 2/20 0.37
SLC6A3 Q01959 3/20 0.36
PPARG P37231 1/20 0.35
PPARA Q07869 1/20 0.35
RAPGEF4 Q8WZA2 1/20 0.34
SLC6A4 P31645 2/20 0.33
SLC6A2 P23975 1/20 0.33
TRPA1 O75762 1/20 0.33
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.33
P2RX7 Q99572 1/20 0.33
DRD4 P21917 1/20 0.33
GRM3 Q14832 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29357072 1.00 CYP4F2 (0.42) CYP4F2CYP4A11MAPTMAPK1GRM2
SCHEMBL6202629 0.84 GRM2 (0.39) CYP4F2CYP4A11MAPTMAPK1GRM2
SCHEMBL8022538 0.84 FFAR1 (0.40) CYP4F2CYP4A11MAPTMAPK1GRM2
SCHEMBL27803608 0.83 PNMT (0.45) MAPTMAPK1GRM2PNMTTAAR1
SCHEMBL29354626 0.82 PIK3CA (0.44) CYP4F2CYP4A11MAPTPNMTTAAR1
SCHEMBL118390 0.82 PIK3CA (0.44) CYP4F2CYP4A11MAPTPNMTTAAR1
SCHEMBL31634179 0.79 MAPT (0.42) MAPTMAPK1GRM2PNMTTAAR1
SCHEMBL4524759 0.79 MAPT (0.42) MAPTMAPK1GRM2PNMTTAAR1
SCHEMBL10128 0.78 IDO1 (0.58) CYP4F2CYP4A11PNMTTAAR1IDO1
SCHEMBL29413271 0.78 IDO1 (0.58) CYP4F2CYP4A11PNMTTAAR1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 330 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119285434-A Preparation method of 3-fluoro-4-chlorobenzyl bromide 上海泰坦科技股份有限公司 2025-01-10 CN claimed
CN-119431371-B Beta-carbolin 3,6, 9-modified derivative and preparation method and application thereof 沈阳药科大学 2026-05-19 CN disclosed
EP-4741397-A1 FUSED TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF Shenzhen Zhongge Biological Technology Co., Ltd. (CN) 2026-05-13 EP disclosed
EP-4737448-A1 SARM1 ENZYME ACTIVITY INHIBITOR AND USE THEREOF Artivila (ShenZhen) Innovation Center, Ltd. (CN) 2026-05-06 EP disclosed
EP-3817742-B1 HETEROCYCLIC SULFONAMIDE DERIVATIVES AND PHARMACEUTICAL USES THEREOF TEMMUNE THERAPEUTICS NV (BE) 2026-04-08 EP disclosed
EP-3704094-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-11 EP disclosed
US-12570642-B2 GLP-IR modulating compounds GILEAD SCIENCES, INC. (US) 2026-03-10 US disclosed
EP-4692085-A2 PROSTAGLANDIN EP4 RECEPTOR ANTAGONIST COMPOUNDS Nxera Pharma UK Limited (GB) 2026-02-11 EP disclosed
EP-4691554-A2 GLP-1R MODULATING COMPOUNDS Gilead Sciences, Inc. (US) 2026-02-11 EP disclosed
EP-4663640-A1 XANTHINE COMPOUND AND USE THEREOF Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) 2025-12-17 EP disclosed
CN-1972916-A Cinnamide compounds EISAI R&D MAN CO LTD (JP) 2007-05-30 CN disclosed
EP-1757591-A1 CINNAMIDE COMPOUND Eisai R&D Management Co., Ltd. (JP) 2007-02-28 EP disclosed
WO-2006030032-A1 NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS JANSSEN PHARMACEUTICA N.V. (BE) 2006-03-23 WO disclosed
US-20060004013-A1 Alzheimer's disease, senile dementia, Down syndrome or amyloidosis; 3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]piperidin-2-one; imidazolyl-functional compounds inhibit production of Amyloid beta 40 and Amyloid beta 42; low hygroscopicity; good solubility EISAI CO., LTD. 2006-01-05 US disclosed
EP-1150952-B1 INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS ASTRAZENECA AB (SE) 2004-10-27 EP disclosed
US-6737435-B1 ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES ASTRAZENECA AB (SE) 2004-05-18 US disclosed
EP-1150952-A1 INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS AstraZeneca AB (SE) 2001-11-07 EP disclosed
US-6271385-B1 FUNGICIDES (SUCH AS THOSE FOR USE IN FARMING AND HORTICULTURE). KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2001-08-07 US disclosed
WO-2000046196-A1 INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS ASTRAZENECA AB (SE) 2000-08-10 WO disclosed
EP-1020441-A1 N-HETEROCYCLIC METHYLPROPYLAMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND GERMICIDES KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2000-07-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060004013-A1 Alzheimer's disease, senile dementia, Down syndrome or amyloidosis; 3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]piperidin-2-one; imidazolyl-functional compounds inhibit production of Amyloid beta 40 and Amyloid beta 42; low hygroscopicity; good solubility PSEN1, APP, BACE1 CYP4F2 4315/4885CYP4A11 2897/4885MAPT 10/4885
US-12570642-B2 GLP-IR modulating compounds GLP1R, GIPR, GPR119 CYP4F2 2439/4885CYP4A11 2025/4885MAPT 4046/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.