Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKBIA | P25963 | 4/20 | 0.64 |
| ▸ | RELA | Q04206 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | SLC40A1 | Q9NP59 | 4/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | MDM4 | O15151 | 1/20 | 0.64 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | SLC10A6 | Q3KNW5 | 1/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11973406 | 0.80 | SLC40A1 (0.61) | NFKBIARELAMEN1KMT2ASLC40A1 | |
| SCHEMBL11973295 | 0.78 | SLC40A1 (1.00) | NFKBIARELAMEN1KMT2ASLC40A1 | |
| SCHEMBL11973610 | 0.78 | NFKBIA (0.74) | NFKBIARELAMEN1KMT2ASLC40A1 | |
| SCHEMBL12475044 | 0.77 | SLC40A1 (0.57) | NFKBIAMEN1KMT2ASLC40A1TDP1 | |
| SCHEMBL7777578 | 0.76 | PDE10A (0.50) | MEN1KMT2ATDP1GAASMN1; SMN2 | |
| SCHEMBL11972815 | 0.74 | SLC40A1 (0.68) | NFKBIARELAMEN1KMT2ASLC40A1 | |
| SCHEMBL11972939 | 0.74 | RELA (1.00) | NFKBIARELAMEN1KMT2ASLC40A1 | |
| SCHEMBL11973574 | 0.74 | RELA (0.75) | NFKBIARELAMEN1KMT2ASLC40A1 | |
| SCHEMBL7451030 | 0.74 | PKM (0.64) | NFKBIARELAMEN1KMT2ASLC40A1 | |
| SCHEMBL5937374 | 0.73 | SLC40A1 (0.70) | NFKBIARELAMEN1KMT2ASLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675526-B1 | NOVEL SULFONAMINOQUINOLINE HEPCIDIN ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2017-02-01 | — | — | EP | disclosed |
| US-9102688-B2 | Sulfonaminoquinoline hepcidin antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2015-08-11 | — | — | US | disclosed |
| US-20140364424-A1 | Novel Sulfonaminoquinoline Hepcidin Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2014-12-11 | — | — | US | disclosed |
| US-20120214803-A1 | Novel Sulfonaminoquinoline Hepcidin Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214803-A1 | Novel Sulfonaminoquinoline Hepcidin Antagonists | HAMP, SLC40A1, FTH1 | NFKBIA 277/4885RELA 1102/4885MEN1 2680/4885 |
| US-20140364424-A1 | Novel Sulfonaminoquinoline Hepcidin Antagonists | HAMP, SLC40A1, FTH1 | NFKBIA 277/4885RELA 1102/4885MEN1 2680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.