Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.30 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.30 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1756774 | 0.69 | CYP11B1 (0.36) | CYP11B1CYP11B2KCNN4TSHRKCNA3 | |
| SCHEMBL8443085 | 0.65 | CYP11B1 (0.36) | CYP11B1CYP11B2KCNN4TSHRKCNA3 | |
| SCHEMBL2036810 | 0.65 | CYP11B1 (0.36) | CYP11B1CYP11B2KCNN4TSHRKCNA3 | |
| SCHEMBL1757361 | 0.65 | CYP11B1 (0.40) | CYP11B1CYP11B2KCNN4TSHRKCNA3 | |
| SCHEMBL9650536 | 0.62 | CYP2B6 (0.46) | CYP11B1CYP11B2KCNN4TSHRALDH1A1 | |
| SCHEMBL198143 | 0.62 | NOTUM (0.45) | CYP11B1CYP11B2KCNN4TSHRKCNA3 | |
| SCHEMBL29268367 | 0.61 | HTT (0.38) | CYP11B1CYP11B2KCNN4TSHRKCNA3 | |
| SCHEMBL1292257 | 0.61 | CYP11B1 (0.44) | CYP11B1CYP11B2KCNN4TSHRKCNA3 | |
| SCHEMBL12787567 | 0.60 | ALDH1A1 (0.39) | CYP11B1CYP11B2TSHRALDH1A1LMNA | |
| SCHEMBL30577371 | 0.59 | CYP11B1 (0.57) | CYP11B1CYP11B2KCNN4TSHRKCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513046-B1 | PROCESS FOR THE PREPARATION OF 4-BROMOMETHYL-[1,1'-BIPHENYL]-2'-CARBONITRILE | SANOFI SA (FR) | 2015-07-08 | — | — | EP | claimed |
| EP-1032557-B1 | METHOD FOR PREPARING BROMOMETHYL-BIPHENYL DERIVATIVES | SANOFI SYNTHELABO (FR) | 2003-09-10 | — | — | EP | claimed |
| US-20020183313-A1 | 1,4-benzodiazepinones and their uses as CCK antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-05 | — | — | US | claimed |
| US-20020002163-A1 | 1,4-benzodiazepinones and their uses as CCK antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-01-03 | — | — | US | claimed |
| US-6291452-B1 | CHOLECYSTOKININ ANTAGONISTS. | FUJISAWA PHARMACETICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | claimed |
| US-6214999-B1 | A BROMINATING AGENT IS REACTED IN A 2 PHASE MEDIUM, UNDER EFFECT PHOTO-IRRADIATION WITH BIPHENYL DERIVATIVE | SANOFI-SYNTHELABO (FR) | 2001-04-10 | — | — | US | claimed |
| EP-1032557-A1 | METHOD FOR PREPARING BROMOMETHYL-BIPHENYL DERIVATIVES | SANOFI-SYNTHELABO (FR) | 2000-09-06 | — | — | EP | claimed |
| EP-0934282-A1 | 1,4-BENZODIAZEPINONES AND THEIR USES AS CCK ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-11 | — | — | EP | claimed |
| WO-1999025681-A1 | METHOD FOR PREPARING BROMOMETHYL-BIPHENYL DERIVATIVES | SANOFI-SYNTHELABO (FR) | 1999-05-27 | — | — | WO | claimed |
| WO-1998015535-A1 | 1,4-BENZODIAZEPINONES AND THEIR USES AS CCK ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-04-16 | — | — | WO | claimed |
| EP-0566020-A1 | Benzimidazoles, pharmaceutical compositions thereof and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-10-20 | — | — | EP | claimed |
| EP-0560330-A2 | Substituted benzimidazolyl derivatives, therapeutic agents containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-09-15 | — | — | EP | claimed |
| EP-0556789-A2 | Substituted biphenyl derivatives, therapeutic agents containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-08-25 | — | — | EP | claimed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | claimed |
| EP-0552765-A1 | Benzimidazoles, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-07-28 | — | — | EP | claimed |
| EP-0479892-A1 | FUSED-RING ARYL SUBSTITUTED IMIDAZOLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-04-15 | — | — | EP | claimed |
| WO-1991000277-A1 | SUBSTITUTED IMIDAZOLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-01-10 | — | — | WO | claimed |
| WO-1991000281-A2 | FUSED-RING ARYL SUBSTITUTED IMIDAZOLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-01-10 | — | — | WO | claimed |
| EP-0324377-A2 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-19 | — | — | EP | claimed |
| WO-1989006233-A1 | ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES AND COMBINATIONS THEREOF WITH DIURETICS AND NSAIDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-13 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020002163-A1 | 1,4-benzodiazepinones and their uses as CCK antagonists | CCKAR, CCKBR, GABRA4 | CYP11B1 212/4885CYP11B2 259/4885KCNN4 262/4885 |
| US-20020183313-A1 | 1,4-benzodiazepinones and their uses as CCK antagonists | CCKAR, CCKBR, GABRA4 | CYP11B1 212/4885CYP11B2 259/4885KCNN4 262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.