SCHEMBL1198548

SCHEMBL1198548

Cc1sc(-c2cc(Cl)cc(C(F)(F)F)c2)nc1Cn1cc(C(=O)O)cn1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 4/20 0.39
ALDH1A1 P00352 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
HSD17B10 Q99714 1/20 0.36
POLB P06746 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MAPT P10636 1/20 0.35
RAF1 P04049 1/20 0.35
NR1H4 Q96RI1 1/20 0.35
CTSS P25774 1/20 0.35
S1PR1 P21453 1/20 0.34
S1PR3 Q99500 1/20 0.34
KLKB1 P03952 1/20 0.34
RXRA P19793 1/20 0.34
RXRB P28702 1/20 0.34
RXRG P48443 1/20 0.34
CETP P11597 1/20 0.34
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1198731 0.90 RXRA (0.37) EGLN1ALDH1A1SMN1; SMN2L3MBTL1NR1H4
SCHEMBL1199073 0.90 EGLN1 (0.38) EGLN1ALDH1A1SMN1; SMN2L3MBTL1NR1H4
SCHEMBL1198939 0.89 MAPT (0.43) L3MBTL1MAPT
SCHEMBL12876109 0.88 L3MBTL1 (0.39) EGLN1SMN1; SMN2L3MBTL1HSD17B10POLB
SCHEMBL1198840 0.86 ALDH1A1 (0.53) EGLN1ALDH1A1SMN1; SMN2MAPTNR1H4
SCHEMBL15418632 0.86 PPARG (0.36) ALDH1A1SMN1; SMN2MAPTRAF1CTSS
SCHEMBL2860124 0.86 FFAR4 (0.39) EGLN1ALDH1A1SMN1; SMN2L3MBTL1NR1H4
SCHEMBL2854619 0.86 CTSS (0.39) EGLN1ALDH1A1SMN1; SMN2NR1H4CTSS
SCHEMBL2859879 0.85 PPARG (0.39) ALDH1A1SMN1; SMN2L3MBTL1CTSSRXRA
SCHEMBL1198313 0.85 ALDH1A1 (0.37) EGLN1ALDH1A1SMN1; SMN2MAPTNR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220128561-A1 METHODS TO DETERMINE WHETHER A SUBJECT IS SUITABLE OF BEING TREATED WITH AN AGONIST OF SOLUBLE GYANYLYL CYCLASE (SGC) BAYER AKTIENGESELLSCHAFT (DE) 2022-04-28 US claimed
EP-3911675-A1 METHODS TO DETERMINE WHETHER A SUBJECT IS SUITABLE OF BEING TREATED WITH AN AGONIST OF SOLUBLE GUANYLYL CYCLASE (SGC) Bayer Aktiengesellschaft (DE) 2021-11-24 EP claimed
CN-113330030-A Method for determining whether a subject is suitable for treatment with an agonist of soluble guanylate cyclase (sGC) 拜耳公司 2021-08-31 CN claimed
WO-2020148379-A1 METHODS TO DETERMINE WHETHER A SUBJECT IS SUITABLE OF BEING TREATED WITH AN AGONIST OF SOLUBLE GUANYLYL CYCLASE (SGC) BAYER AKTIENGESELLSCHAFT (DE) 2020-07-23 WO claimed
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-06-21 US claimed
EP-3291811-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) Bayer Pharma Aktiengesellschaft (DE) 2018-03-14 EP claimed
WO-2016177660-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-11-10 WO claimed
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS BAYER PHARMA AKTIENGESELl SCHAFT (DE) 2016-06-09 US claimed
EP-3024455-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS Bayer Pharma Aktiengesellschaft (DE) 2016-06-01 EP claimed
EP-2531187-B1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS ADVERIO PHARMA GMBH (DE) 2015-08-12 EP claimed
WO-2015011086-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-01-29 WO claimed
US-8461348-B2 Heterocyclic derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-06-11 US claimed
US-20130035340-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-02-07 US claimed
EP-2531187-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS Bayer Intellectual Property GmbH (DE) 2012-12-12 EP claimed
WO-2011095534-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2011-08-11 WO claimed
WO-2011095553-A1 SGC STIMULATORS OR SGC ACTIVATORS IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF ERECTILE DYSFUNCTION BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2011-08-11 WO claimed
US-20110028493-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-02-03 US claimed
EP-2264017-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2010-12-22 EP claimed
US-12427131-B2 Stimulators and/or activators of soluble guanylate cyclase (sGC) in combination with an inhibitor of neutral endopeptidase (NEP inhibitor) and/or an angiotensin AII antagonist and the use thereof BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2025-09-30 US disclosed
EP-2264017-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2010-12-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130035340-A1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS PDE5A, PDE3B, PDE3A EGLN1 661/4885ALDH1A1 2898/4885SMN1; SMN2 3541/4885
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) PDE5A, PDE2A, PDE3A EGLN1 1359/4885ALDH1A1 3223/4885SMN1; SMN2 779/4885
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS PDE5A, PDE3A, GMPS EGLN1 2487/4885ALDH1A1 3812/4885SMN1; SMN2 2810/4885
US-20110028493-A1 HETEROCYCLIC DERIVATIVE AND USE THEREOF PDE3B, PDE5A, PDE2A EGLN1 829/4885ALDH1A1 1037/4885SMN1; SMN2 2057/4885
US-12427131-B2 Stimulators and/or activators of soluble guanylate cyclase (sGC) in combination with an inhibitor of neutral endopeptidase (NEP inhibitor) and/or an angiotensin AII antagonist and the use thereof MME, ECE1, REN EGLN1 1031/4885ALDH1A1 3873/4885SMN1; SMN2 1057/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.