Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17100175 | 0.77 | CES2 (0.48) | CES2CES1LCKFYNDAO | |
| SCHEMBL1198646 | 0.76 | NR4A1 (0.46) | CES2CES1ANO1MDM2MAP2K1 | |
| SCHEMBL31612030 | 0.74 | CES2 (0.54) | CES2CES1LCKFYNDAO | |
| SCHEMBL1309846 | 0.72 | TUBB4A (0.50) | — | |
| SCHEMBL2166098 | 0.71 | CES2 (0.71) | CES2CES1LCKFYNDAO | |
| SCHEMBL1199143 | 0.71 | MAP2K1 (0.47) | HSD17B14MAPK14MAP2K1 | |
| SCHEMBL15318295 | 0.70 | CES2 (0.48) | CES2CES1LCKFYNDAO | |
| SCHEMBL78403 | 0.70 | MAP2K1 (0.53) | CES2CES1ANO1PTPN1MAP2K2 | |
| SCHEMBL17112809 | 0.70 | CES2 (0.44) | CES2CES1LCKFYNDAO | |
| SCHEMBL8067455 | 0.69 | GABRA1 (0.51) | HDAC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812112-B1 | Benzodiazepine derivatives as ROCK kinases inhibitors | GLAXOSMITHKLINE LLC (US) | 2011-04-27 | — | — | EP | disclosed |
| EP-1812112-B1 | Benzodiazepine derivatives as ROCK kinases inhibitors | GLAXOSMITHKLINE LLC (US) | 2011-04-27 | — | — | EP | disclosed |
| US-7888503-B2 | Benzodiazepine derivatives that inhibit rock | GLAXOSMITHKLINE LLC (US) | 2011-02-15 | — | — | US | disclosed |
| US-7888503-B2 | Benzodiazepine derivatives that inhibit rock | GLAXOSMITHKLINE LLC (US) | 2011-02-15 | — | — | US | disclosed |
| US-20090143366-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
| US-20090143366-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
| EP-1812112-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006044753-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143366-A1 | CHEMICAL COMPOUNDS | ROCK2, ROCK1, ABL1 | CES2 1589/4885CES1 3374/4885LCK 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.