SCHEMBL78403

SCHEMBL78403

O=C(O)c1cc(I)ccc1F

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP2K1 Q02750 8/20 0.53
MAP2K2 P36507 3/20 0.53
PTPRC P08575 1/20 0.50
PTPN2 P17706 1/20 0.50
PTPN1 P18031 1/20 0.50
PTPRA P18433 1/20 0.50
PTPRB P23467 1/20 0.50
PTPRE P23469 1/20 0.50
PTPN6 P29350 1/20 0.50
ANO1 Q5XXA6 1/20 0.44
CES2 O00748 1/20 0.43
CES1 P23141 1/20 0.43
TPMT P51580 1/20 0.43
CYP3A4 P08684 1/20 0.42
KDM4E B2RXH2 1/20 0.42
ASPH Q12797 1/20 0.42
KDM8 Q8N371 1/20 0.42
IDO1 P14902 1/20 0.42
ALB P02768 1/20 0.41
MRGPRX4 Q96LA9 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2920384 0.83 MAP2K1 (0.57) MAP2K1MAP2K2PTPRCPTPN2PTPN1
SCHEMBL1306850 0.81 ALDH1A1 (0.52) MAP2K1MAP2K2PTPRCPTPN2PTPN1
SCHEMBL1477485 0.81 MAP2K1 (0.54) MAP2K1MAP2K2PTPRCPTPN2PTPN1
SCHEMBL1440124 0.81 CES2 (0.42) MAP2K1MAP2K2PTPRCPTPN2PTPN1
SCHEMBL522679 0.79 PTPN1 (0.55) MAP2K1MAP2K2PTPRCPTPN2PTPN1
SCHEMBL30531094 0.78 TRPV1 (0.40) MAP2K1MAP2K2PTPRCPTPN2PTPN1
SCHEMBL1689979 0.78 TRPV1 (0.40) MAP2K1MAP2K2PTPRCPTPN2PTPN1
SCHEMBL1308634 0.78 PTPRC (0.57) MAP2K1MAP2K2PTPRCPTPN2PTPN1
SCHEMBL22089726 0.77 AR (0.41) MAP2K1MAP2K2PTPRCPTPN2PTPN1
SCHEMBL28641470 0.77 KMT2A (0.44) MAP2K1MAP2K2ANO1CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 326 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 CN claimed
CN-106008195-B The preparation method of 2,4- of one kind, bis- fluoro- 5- iodo-benzoic acids 绍兴文理学院 2018-08-03 CN claimed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 EP disclosed
US-20250331521-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING AN OXIME GROUP, AGRICULTURAL OR HORTICULTURAL HERBICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE COMPOUND OR THE HERBICIDE NIHON NOHYAKU CO., LTD. (JP) 2025-10-30 US disclosed
EP-4480950-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING OXIME GROUP, AGRICULTURAL/HORTICULTURAL HERBICIDE CONTAINING SAID COMPOUND, AND USE OF BOTH OF FOREGOING Nihon Nohyaku Co., Ltd. (JP) 2024-12-25 EP disclosed
CN-118891254-A Nitrogen-containing heterocyclic compound having oxime group, agrohorticultural herbicide containing the same, and method of using the same 日本农药株式会社 2024-11-01 CN disclosed
EP-3584239-B1 O-AMINOHETEROARYL ALKYNYL-CONTAINING COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF SHANGHAI INST MATERIA MEDICA CAS (CN) 2024-09-11 EP disclosed
CN-113164459-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-03 CN disclosed
EP-3632910-B1 3,4-DIHYDROQUINOLINONES AS FXR RECEPTOR AGONISTS CSPC ZHONGQI PHARMACEUTICAL TECH SHIJIAZHUANG CO LTD (CN) 2024-07-17 EP disclosed
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 CN disclosed
EP-1140851-A1 4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2001-10-10 EP disclosed
WO-2001070706-A2 4-OXO-1,4-DIHYDRO-3-CINNOLINECARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2001-09-27 WO disclosed
US-6248739-B1 DNA POLYMERASE INHIBITORS EFFECTIVE AGAINST HERPESVIRUSES PHARMACIA & UPJOHN COMPANY 2001-06-19 US disclosed
US-6248736-B1 DNA POLYMERASE INHIBITORS EFFECTIVE AGAINST HERPESVIRUSES PHARMACIA & UPJOHN COMPANY 2001-06-19 US disclosed
WO-2000040563-A1 4-OXO-1,4-DIHYDRO-3-QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2000-07-13 WO disclosed
WO-2000040561-A1 QUINOLINECARBOXAMIDES AS ANTIVIRAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 2000-07-13 WO disclosed
EP-0327190-B1 Pyrido(2,3-d)pyrimidine derivatives UNIV PRINCETON (US) 1993-12-08 EP disclosed
US-4889859-A ANTITUMOR AGENTS THE TRUSTEES OF PRINCETON UNIVERSITY (US) 1989-12-26 US disclosed
EP-0327190-A1 Pyrido(2,3-d)pyrimidine derivatives THE TRUSTEES OF PRINCETON UNIVERSITY (US) 1989-08-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250331521-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING AN OXIME GROUP, AGRICULTURAL OR HORTICULTURAL HERBICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE COMPOUND OR THE HERBICIDE DDT, HDHD5, HAAO MAP2K1 1503/4885MAP2K2 1900/4885PTPRC 2069/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH MAP2K1 3333/4885MAP2K2 3659/4885PTPRC 2366/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.