Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11987000 | 0.76 | POLB (0.44) | L3MBTL1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL28256540 | 0.75 | ALDH1A1 (0.49) | L3MBTL1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL9806762 | 0.73 | ADRB2 (0.47) | L3MBTL1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL1747972 | 0.71 | KMT2A (0.52) | L3MBTL1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL5068457 | 0.71 | KMT2A (0.52) | L3MBTL1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL8381423 | 0.70 | POLB (0.47) | L3MBTL1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL4277222 | 0.69 | SLC6A3 (0.43) | L3MBTL1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL11651911 | 0.69 | TSHR (0.39) | KMT2ATSHRRAB9AMAPTHSD17B10 | |
| SCHEMBL14571476 | 0.69 | KMT2A (0.68) | L3MBTL1KMT2ALMNATSHRNPC1 | |
| SCHEMBL11365527 | 0.68 | MAPT (0.56) | KMT2ALMNACYP1A2CYP3A4MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247422-B2 | Use of condensed pyrimidine derivatives for the treatment of rheumatoid arthritis | STOICESCU DAN (CH) | 2012-08-21 | — | — | US | disclosed |
| US-20100160329-A1 | USE OF CONDENSED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | STOICESCU DAN | 2010-06-24 | — | — | US | disclosed |
| EP-1958632-A1 | Use of condensed pyrimidine derivatives for the treatment of autoimmune and inflammatory diseases | Stoicescu, Dan (CY) | 2008-08-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160329-A1 | USE OF CONDENSED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | CCR8, HRH4, CXCL8 | L3MBTL1 3534/4885KMT2A 2040/4885ADRB2 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.