Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | USP5 | P45974 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8381423 | 0.81 | POLB (0.47) | POLBTSHRUSP5NPC1RAB9A | |
| SCHEMBL28256540 | 0.78 | ALDH1A1 (0.49) | POLBTSHRUSP5NPC1RAB9A | |
| SCHEMBL9806762 | 0.77 | ADRB2 (0.47) | POLBTSHRUSP5NPC1RAB9A | |
| SCHEMBL11986999 | 0.76 | L3MBTL1 (0.48) | TSHRNPC1RAB9AADRB2ADRB1 | |
| SCHEMBL9064982 | 0.75 | KMO (0.60) | POLBTSHRMAPTKDM4EHIF1A | |
| SCHEMBL9420250 | 0.75 | KMO (0.57) | POLBTSHRADRB2ADRB1ADRB3 | |
| Hydrochloric Acid SCHEMBL6480182 | 0.74 | KMO (0.61) | POLBTSHRMAPTKDM4EHIF1A | |
| SCHEMBL7188801 | 0.72 | TSHR (0.60) | POLBTSHRNPC1RAB9ALMNA | |
| SCHEMBL6502449 | 0.72 | TSHR (0.60) | POLBTSHRNPC1RAB9ALMNA | |
| SCHEMBL27392653 | 0.71 | ADRB2 (0.41) | POLBTSHRNPC1RAB9AADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247422-B2 | Use of condensed pyrimidine derivatives for the treatment of rheumatoid arthritis | STOICESCU DAN (CH) | 2012-08-21 | — | — | US | disclosed |
| US-20100249141-A1 | NOVEL INHIBITORS OF FOLIC ACID-DEPENDENT ENZYMES | STOICESCU DAN | 2010-09-30 | — | — | US | disclosed |
| US-20100160329-A1 | USE OF CONDENSED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | STOICESCU DAN | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160329-A1 | USE OF CONDENSED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | CCR8, HRH4, CXCL8 | POLB 2036/4885TSHR 261/4885USP5 3283/4885 |
| US-20100249141-A1 | NOVEL INHIBITORS OF FOLIC ACID-DEPENDENT ENZYMES | FOLR2, FOLR1, DHFR | POLB 1480/4885TSHR 295/4885USP5 1985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.