Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of (S)-Lorazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.58 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.58 |
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.58 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.58 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.58 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.58 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.58 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.58 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.58 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.58 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.58 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.58 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.58 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 0.58 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 0.58 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | ALB | P02768 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lorazepam SCHEMBL5271784 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL29516559 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| (R)-Lorazepam SCHEMBL26962 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL29388543 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL29358033 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL13747464 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL26961 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL28931472 | 0.99 | LMNA (0.97) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL5908139 | 0.99 | LMNA (0.97) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL6500339 | 0.99 | LMNA (0.97) | LMNAPGRMEN1ALBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5472 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4725506-A2 | THE PEPTIDOMIMETIC COMPOUND (R)-2-AMINO-N-((S)-L-(((S)-5-AMINO-L-(3-BENZYL-1,2,4-OXADIAZOL-5-YL)PENTYL)AMINO)-3-(4-HYDROXY-2,6-DIMETHYLPHENYL)-1-OXOPROPAN-2-YL)-5-GUANIDINOPENTANAMIDE FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | Stealth BioTherapeutics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-3986401-B1 | THE PEPTIDOMIMETIC COMPOUND (R)-2-AMINO-N-((S)-L-(((S)-5-AMINO-L-(3-BENZYL-1,2,4-OXADIAZOL-5-YL)PENTYL)AMINO)-3-(4-HYDROXY-2,6-DIMETHYLPHENYL)-1-OXOPROPAN-2-YL)-5-GUANIDINOPENTANAMIDE FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | STEALTH BIOTHERAPEUTICS INC (US) | 2026-01-28 | — | — | EP | claimed |
| US-12525764-B2 | Devices for generation of electromagnetic radiation of predetermined profile | Terahertz Group Ltd. (IL) | 2026-01-13 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| CN-119790152-A | Treatment of neurological disorders using modulators of UNC13A gene transcripts | 奎里斯公司 | 2025-04-08 | — | — | CN | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| US-20250085301-A1 | DATE RAPE DRUG DETECTION DEVICE AND METHOD OF USING SAME | EHRLICH ELAN (IL) | 2025-03-13 | — | — | US | claimed |
| WO-2025052373-A1 | DATE RAPE DRUG DETECTION DEVICE AND METHOD OF USING SAME | EHRLICH ELAN (IL) | 2025-03-13 | — | — | WO | claimed |
| US-20250076321-A1 | DATE RAPE DRUG DETECTION DEVICE AND METHOD OF USING SAME | EHRLICH ELAN (IL) | 2025-03-06 | — | — | US | claimed |
| CN-2186002-Y | Sealed safety nail clippers | WANG CHENGFA (CN) | 1994-12-28 | — | — | CN | claimed |
| EP-0398907-B1 | IMPROVED APPARATUS FOR REPAIR OF SHATTERPROOF GLASS | BELRON INT NV (AN) | 1994-12-14 | — | — | EP | claimed |
| CN-2145454-Y | Sealed safety circuit connector | LI MINGYI (CN) | 1993-11-03 | — | — | CN | claimed |
| CN-2135836-Y | CLOSED SAFETY FUSE | WANG ENHAI (CN) | 1993-06-09 | — | — | CN | claimed |
| CN-1056157-A | AUTOMATIC CONTROL AND ALARM SAFETY DEVICE FOR FUEL GAS | ZHANG SHANLI (CN) | 1991-11-13 | — | — | CN | claimed |
| CN-2073009-U | SAFETY ENCLOSED FENCE | LABOUR SERVICE CO HENGYANG POW (CN) | 1991-03-13 | — | — | CN | claimed |
| CN-2064914-U | GAS AUTOMATIC CONTROL ALARM SAFETY DEVICE | ZHANG SHANLI (CN) | 1990-10-31 | — | — | CN | claimed |
| CN-2032364-U | DOUBLE PURPOSE SAFE PLUG AND SOKET (PREVENTING ELECTRIC SHOCK, EXPLOSION PROTECTION, ANTICORROSION, ANTICOLLISION) | LIU WEI (CN) | 1989-02-08 | — | — | CN | claimed |
| CN-87215423-U | SEALED SAFETY EFFICIENCY ELECTRIC FURNACE | — | 1988-08-24 | — | — | CN | claimed |
| WO-1984004985-A1 | LASER SECURITY SYSTEM | HUGHES TECHNOLOGY PTY LTD (AU) | 1984-12-20 | — | — | WO | claimed |