Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of (R)-Lorazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.58 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.58 |
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.58 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.58 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.58 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.58 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.58 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.58 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.58 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.58 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.58 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.58 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.58 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 0.58 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 0.58 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | ALB | P02768 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lorazepam SCHEMBL5271784 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL29516559 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL29388543 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL29358033 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| (S)-Lorazepam SCHEMBL120031 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL13747464 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL26961 | 1.00 | LMNA (1.00) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL28931472 | 0.99 | LMNA (0.97) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL5908139 | 0.99 | LMNA (0.97) | LMNAPGRMEN1ALBKMT2A | |
| Lorazepam SCHEMBL6500339 | 0.99 | LMNA (0.97) | LMNAPGRMEN1ALBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 40411 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12624037-B2 | Method of treating agitation, aggressive behavior, and impulse control disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12624036-B2 | Method of treating post-traumatic stress disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12616653-B2 | Solid orodispersible pharmaceutical composition in film containing lorazepam | ALTERGON S.A. (CH) | 2026-05-05 | — | — | US | claimed |
| US-20260115161-A1 | 2-HYDROXY-OCTADECENE-9-CIS-OATE FOR USE IN THE TREATMENT OF ONCOLOGICAL PATHOLOGIES AND NEUROPATHIC PAIN | LAMINAR PHARMACEUTICALS S A (ES) | 2026-04-30 | — | — | US | claimed |
| WO-2026090360-A1 | FUSED PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, HEARING LOSS, AND MENIERE'S DISEASE | OVID THERAPEUTICS INC. (US) | 2026-04-30 | — | — | WO | claimed |
| US-20260108529-A1 | FUSED AMINO PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, ACUTE SENSORINEURAL HEARING LOSS, AGE-RELATED HEARING LOSS, AND MENIERE'S DISEASE | OVID THERAPEUTICS INC (US) | 2026-04-23 | — | — | US | claimed |
| EP-4725506-A2 | THE PEPTIDOMIMETIC COMPOUND (R)-2-AMINO-N-((S)-L-(((S)-5-AMINO-L-(3-BENZYL-1,2,4-OXADIAZOL-5-YL)PENTYL)AMINO)-3-(4-HYDROXY-2,6-DIMETHYLPHENYL)-1-OXOPROPAN-2-YL)-5-GUANIDINOPENTANAMIDE FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | Stealth BioTherapeutics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| US-12594256-B2 | A19-144, A2-73 and certain anticholinesterase inhibitor compositions and method for anti-seizure therapy | ANAVEX LIFE SCIENCES CORP. (US) | 2026-04-07 | — | — | US | claimed |
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| US-20260092932-A1 | METHODS AND COMPOSITIONS FOR THE DETECTION, DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDER | THE JOHNSON CENTER FOR CHILD HEALTH AND DEV (US) | 2026-04-02 | — | — | US | claimed |
| EP-0156592-A2 | Substained release pharmaceutical capsules | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-10-02 | — | — | EP | claimed |
| WO-1985004100-A1 | SUSTAINED RELEASE PHARMACEUTICAL CAPSULES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-09-26 | — | — | WO | claimed |
| EP-0151245-A2 | Soporific comprising lorazepam | MEDICHEMIE AG (CH) | 1985-08-14 | — | — | EP | claimed |
| EP-0110955-A1 | BRAIN-SPECIFIC DRUG DELIVERY. | UNIV FLORIDA (US) | 1984-06-20 | — | — | EP | claimed |
| EP-0098113-A1 | A combination of beta-adrenoceptor antagonists and anxiolytic agents | AYERST, MCKENNA AND HARRISON INC. (CA) | 1984-01-11 | — | — | EP | claimed |
| WO-1983003968-A1 | BRAIN-SPECIFIC DRUG DELIVERY | UNIVERSITY OF FLORIDA (US) | 1983-11-24 | — | — | WO | claimed |
| US-4316897-A | TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | claimed |
| EP-0025546-A2 | Therapeutical use of tranquillizing benzodiazepine derivatives and mixtures containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-03-25 | — | — | EP | claimed |
| US-4028466-A | Analgesic compositions comprising dextro-propoxyphene and benzodiazepine and process | BERGER FRANK M | 1977-06-07 | — | — | US | claimed |
| US-4028467-A | Analgesic compositions comprising levo-propoxyphene and benzo diazepine and process | BERGER FRANK M | 1977-06-07 | — | — | US | claimed |