Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9319102 | 0.91 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1RAB9ALMNATP53 | |
| SCHEMBL17417665 | 0.91 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1RAB9ALMNATP53 | |
| SCHEMBL9319718 | 0.76 | KDM4E (0.59) | SMN1; SMN2ALDH1A1HPGDKDM4EHTT | |
| SCHEMBL12877370 | 0.75 | RAB9A (0.44) | SMN1; SMN2ALDH1A1RAB9ALMNATP53 | |
| SCHEMBL2978428 | 0.74 | KDM4E (0.67) | SMN1; SMN2ALDH1A1HPGDKDM4EHTT | |
| SCHEMBL10697569 | 0.73 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1RAB9ALMNATP53 | |
| SCHEMBL29415457 | 0.73 | KDM4E (0.56) | SMN1; SMN2ALDH1A1HPGDKDM4EHTT | |
| SCHEMBL2807362 | 0.73 | KDM4E (0.56) | SMN1; SMN2ALDH1A1HPGDKDM4EHTT | |
| SCHEMBL7002487 | 0.73 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1RAB9ALMNATP53 | |
| SCHEMBL11221002 | 0.72 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1RAB9ALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046142-A1 | ANTIBIOTIC COMPOUNDS | NORTHEASTERN UNIVERSITY (US) | 2011-02-24 | — | — | US | disclosed |
| EP-2167074-A2 | ANTIBIOTIC COMPOUNDS | NorthEastern University (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156610-A2 | ANTIBIOTIC COMPOUNDS | NORTHEASTERN UNIVERSITY (US) | 2008-12-24 | — | — | WO | disclosed |
| US-5019570-A | Antibioics | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046142-A1 | ANTIBIOTIC COMPOUNDS | AADAC, SPOUT1, NRDC | SMN1; SMN2 4615/4885ALDH1A1 1513/4885RAB9A 986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.