Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | LPAR1 | Q92633 | 11/20 | 0.46 |
| ▸ | LPAR5 | Q9H1C0 | 10/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 5/20 | 0.39 |
| ▸ | CA1 | P00915 | 5/20 | 0.39 |
| ▸ | CA2 | P00918 | 5/20 | 0.39 |
| ▸ | CA4 | P22748 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3895438 | 0.80 | OPRM1 (0.64) | OPRM1OPRD1OPRK1LPAR1LPAR5 | |
| SCHEMBL14026038 | 0.80 | OPRM1 (0.60) | OPRM1OPRD1OPRK1LPAR1LPAR5 | |
| SCHEMBL3691735 | 0.79 | OPRM1 (0.56) | OPRM1OPRD1OPRK1LPAR1LPAR5 | |
| SCHEMBL12018645 | 0.74 | L3MBTL1 (0.49) | CA12CA1CA2CA4 | |
| SCHEMBL3695128 | 0.71 | LPAR1 (0.46) | OPRM1OPRD1OPRK1LPAR1LPAR5 | |
| SCHEMBL4956601 | 0.70 | CA12 (0.49) | CA12CA1CA2CA4 | |
| SCHEMBL6187612 | 0.70 | LPAR1 (0.49) | OPRM1OPRD1OPRK1LPAR1LPAR5 | |
| SCHEMBL28746888 | 0.70 | KMT2A (0.50) | CA12CA1CA2CA4 | |
| SCHEMBL6672371 | 0.70 | OPRM1 (0.56) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5739117 | 0.68 | LPAR1 (0.59) | LPAR1LPAR5ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2208727-B1 | Diaryl ethers as opioid receptor antagonist | LILLY CO ELI (US) | 2012-08-29 | — | — | EP | disclosed |
| EP-2208727-A1 | Diaryl ethers as opioid receptor antagonist | Eli Lilly & Company (US) | 2010-07-21 | — | — | EP | disclosed |