Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11270534 | 0.78 | GAA (0.42) | POLBHCAR1MAPTKDM4EALDH1A1 | |
| SCHEMBL8386512 | 0.74 | POLB (0.50) | POLBHCAR1MAPTKDM4ETDP1 | |
| SCHEMBL11266362 | 0.74 | CASP1 (0.42) | POLBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL17537377 | 0.72 | MAPT (0.59) | POLBHCAR1MAPTKDM4ETDP1 | |
| SCHEMBL11266923 | 0.72 | SMN1; SMN2 (0.47) | POLBMAPTMEN1KMT2AL3MBTL1 | |
| SCHEMBL75271 | 0.69 | POLB (0.39) | POLBHCAR1MAPTKDM4ETDP1 | |
| SCHEMBL3303708 | 0.69 | ALDH1A1 (0.53) | POLBHCAR1MAPTKDM4ETDP1 | |
| SCHEMBL7133435 | 0.69 | GSK3A (0.48) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL20596412 | 0.68 | DRD2 (0.45) | HCAR1MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL17931795 | 0.68 | L3MBTL1 (0.51) | POLBHCAR1MAPTKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802866-B2 | Pyridinylimidazolone derivatives for the inhibition of PI3 kinases | MERCK PATENT GMBH (DE) | 2014-08-12 | — | — | US | disclosed |
| US-20120220587-A1 | PYRIDINYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF PI3 KINASES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220587-A1 | PYRIDINYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF PI3 KINASES | PIK3R5, CDK20, PIK3R3 | POLB 3212/4885HCAR1 1969/4885MAPT 3523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.