Ofornine

Ofornine

SCHEMBL120272

O=C(c1ccccc1Nc1ccncc1)N1CCCCC1

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 4/20 0.62
▸ NPSR1 Q6W5P4 3/20 0.62
▸ KMT2A Q03164 3/20 0.62
▸ CYP2C9 P11712 2/20 0.62
▸ HTT P42858 2/20 0.62
▸ L3MBTL1 Q9Y468 2/20 0.62
▸ MEN1 O00255 1/20 0.62
▸ CYP1A2 P05177 1/20 0.62
▸ CYP3A4 P08684 1/20 0.62
▸ CYP2D6 P10635 1/20 0.62
▸ CYP2C19 P33261 1/20 0.62
▸ ADRA1A P35348 2/20 0.52
▸ ADRA1B P35368 2/20 0.52
▸ ADRA1D P25100 1/20 0.52
▸ SMN1; SMN2 Q16637 3/20 0.51
▸ KDM4E B2RXH2 3/20 0.51
▸ MAPT P10636 1/20 0.51
▸ RXFP1 Q9HBX9 1/20 0.48
▸ ALDH1A1 P00352 1/20 0.48
▸ HSD17B10 Q99714 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10838059 1.00 LMNA (0.62) LMNANPSR1KMT2ACYP2C9HTT
Ofornine SCHEMBL30560632 1.00 LMNA (0.62) LMNANPSR1KMT2ACYP2C9HTT
SCHEMBL10838011 1.00 LMNA (0.62) LMNANPSR1KMT2ACYP2C9HTT
SCHEMBL10837621 0.99 LMNA (0.60) LMNANPSR1KMT2ACYP2C9HTT
SCHEMBL10838123 0.86 LMNA (0.63) LMNANPSR1KMT2ACYP2C9HTT
SCHEMBL10838817 0.86 SMN1; SMN2 (0.56) LMNANPSR1KMT2ACYP2C9HTT
SCHEMBL10838784 0.85 NPSR1 (0.50) LMNANPSR1KMT2ACYP2C9HTT
SCHEMBL10990701 0.84 NPSR1 (0.67) LMNANPSR1KMT2ACYP2C9HTT
SCHEMBL10838194 0.84 SMO (0.49) LMNANPSR1KMT2ACYP2C9HTT
SCHEMBL10837980 0.84 KMT2A (0.47) LMNANPSR1KMT2ACYP2C9HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 216 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 — — CN claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 — — EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 — — WO claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 — — US claimed
US-20020115655-A1 Such as S-(4-methoxybenzyl)-N-(2-(N',N'-dimethylamino)ethyl) thiosalicylamide; for treatment of cardiovascular disorders MASSACHUSETTS COLLEGE OF PHARMACY 2002-08-22 — — US claimed
US-4610991-A Antihypertensive pyridylaminobenzamide compounds STERLING DRUG INC. (US) 1986-09-09 — — US claimed
EP-0098951-A2 Aminobenzamide derivatives and preparation thereof STERLING DRUG INC. (US) 1984-01-25 — — EP claimed
EP-4706683-A2 CHEWABLE FORMULATIONS Elanco Tiergesundheit AG (CH) 2026-03-11 — — EP disclosed
US-12296085-B2 Method for extracorporeal treatment of preeclampsia and related disorders ImMutriX Therapeutics, Inc. (US) 2025-05-13 — — US disclosed
EP-3689357-B1 COMPOSITIONS FOR CELLULAR RESTORATION AND METHODS OF MAKING AND USING SAME ADVANCED REGEN MEDICAL TECH LLC (US) 2024-12-04 — — EP disclosed
WO-2024215303-A1 NOVEL DRUG DELIVERY SYSTEMS AND METHODS OF MAKING AND USING SAME THE TEXAS A&M UNIVERSITY SYSTEM (US) 2024-10-17 — — WO disclosed
US-20240294909-A1 AGENTS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF HYPOXIA AND ISCHEMIA-RELATED DISORDERS MERAND PHARMACEUTICALS INC (US) 2024-09-05 — — US disclosed
US-20240247313-A1 SEROTONIN TRANSPORTER GENE AND TREATMENT OF OPIOID-RELATED DISORDERS UNIVERSITY OF VIRGINIA PATENT FOUNDATION 2024-07-25 — — US disclosed
WO-1999030690-A1 ORAL DELIVERY FORMULATION AXIA THERAPEUTICS, INC. (US) 1999-06-24 — — WO disclosed
EP-0909183-A2 DHA-PHARMACEUTICAL AGENT CONJUGATES Neuromedica, Inc. (US) 1999-04-21 — — EP disclosed
US-5795909-A ANTICARCINOGENIC AND ANTITUMOR AGENTS; BREAST, COLON, OVARIANCANCERS NEUROMEDICA, INC. (US) 1998-08-18 — — US disclosed
WO-1997044063-A2 DHA-PHARMACEUTICAL AGENT CONJUGATES NEUROMEDICA, INC. (US) 1997-11-27 — — WO disclosed
US-4610991-A Antihypertensive pyridylaminobenzamide compounds STERLING DRUG INC. (US) 1986-09-09 — — US disclosed
EP-0029171-B1 AZOLYLOXY-CARBOXYLIC ACID N-OXY-AMIDES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE, HERBICIDES CONTAINING THEM AND THEIR PREPARATION BAYER AG (DE) 1984-03-21 — — EP disclosed
EP-0098951-A2 Aminobenzamide derivatives and preparation thereof STERLING DRUG INC. (US) 1984-01-25 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240247313-A1 SEROTONIN TRANSPORTER GENE AND TREATMENT OF OPIOID-RELATED DISORDERS SLC6A4, SLC6A3, SLC6A2 LMNA 1977/4885NPSR1 82/4885KMT2A 1923/4885
US-20020115655-A1 Such as S-(4-methoxybenzyl)-N-(2-(N',N'-dimethylamino)ethyl) thiosalicylamide; for treatment of cardiovascular disorders CACNA1G, CACNA1F, CACNA1H LMNA 2103/4885NPSR1 2488/4885KMT2A 2686/4885
US-12296085-B2 Method for extracorporeal treatment of preeclampsia and related disorders TEK, FLT4, PGF LMNA 2393/4885NPSR1 2570/4885KMT2A 2469/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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