Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355515 | 0.81 | POLB (0.44) | ALDH1A1MEN1KMT2AHSD17B10L3MBTL1 | |
| SCHEMBL2990110 | 0.81 | ALDH1A1 (0.46) | ALDH1A1CYP2C9MEN1KMT2AHSD17B10 | |
| SCHEMBL10414873 | 0.75 | ALDH1A1 (0.58) | ALDH1A1CYP2C9MEN1KMT2AHSD17B10 | |
| SCHEMBL28319827 | 0.71 | ALDH1A1 (0.50) | ALDH1A1CYP2C9MEN1KMT2AHSD17B10 | |
| SCHEMBL14854458 | 0.70 | MKNK1 (0.41) | — | |
| SCHEMBL1202884 | 0.69 | NPC1 (0.36) | ALDH1A1CYP2C9MEN1KMT2APKM | |
| SCHEMBL8115003 | 0.67 | ALDH1A1 (0.59) | ALDH1A1CYP2C9MEN1KMT2AHSD17B10 | |
| SCHEMBL5953902 | 0.67 | ALDH1A1 (0.64) | ALDH1A1CYP2C9MEN1KMT2AHSD17B10 | |
| SCHEMBL30646274 | 0.67 | ALDH1A1 (0.59) | ALDH1A1CYP2C9MEN1KMT2AHSD17B10 | |
| SCHEMBL8876086 | 0.67 | ALDH1A1 (0.59) | ALDH1A1CYP2C9MEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884098-B2 | 2-{[5-Fluoro-2-({3-[2-(4-morpholinyl)ethyl]phenyl}amino)-4-pyrimidinyl]amino}-N-(2-hydroxyethyl)benzamide, useful in the treatment of cancer | GLAXOSMITHKLINE LLC (US) | 2011-02-08 | — | — | US | claimed |
| US-20100016318-A1 | ANTHRANILAMIDE INHIBITORS OF AURORA KINASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-21 | — | — | US | claimed |
| US-7884098-B2 | 2-{[5-Fluoro-2-({3-[2-(4-morpholinyl)ethyl]phenyl}amino)-4-pyrimidinyl]amino}-N-(2-hydroxyethyl)benzamide, useful in the treatment of cancer | GLAXOSMITHKLINE LLC (US) | 2011-02-08 | — | — | US | disclosed |
| US-20110028318-A1 | HERBICIDAL COMPOUNDS BASED ON N-AZINYL-N'-PYRIDYLSULPHONYLUREAS | BAYER CROPSCIENCE AG (DE) | 2011-02-03 | — | — | US | disclosed |
| US-20110028318-A1 | HERBICIDAL COMPOUNDS BASED ON N-AZINYL-N'-PYRIDYLSULPHONYLUREAS | BAYER CROPSCIENCE AG (DE) | 2011-02-03 | — | — | US | disclosed |
| CN-101903379-A | Herbicidal compound based on N-azine group-N '-pyridyl sulfonylurea | BAYER CROPSCIENCE AG | 2010-12-01 | — | — | CN | disclosed |
| EP-2225234-A1 | HERBICIDAL COMPOUNDS BASED ON N-AZINYL-N'-PYRIDYLSULPHONYLUREAS | Bayer CropScience Aktiengesellschaft (DE) | 2010-09-08 | — | — | EP | disclosed |
| US-20100016318-A1 | ANTHRANILAMIDE INHIBITORS OF AURORA KINASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-21 | — | — | US | disclosed |
| US-7625903-B2 | Anticancer agent; N-(1-methylethyl)-2-[(5-methyl-2-{[3-(4-methyl-2-oxo-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)amino]benzamide | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-01 | — | — | US | disclosed |
| WO-2009080182-A1 | HERBICIDAL COMPOUNDS BASED ON N-AZINYL-N'-PYRIDYLSULPHONYLUREAS | BAYER CROPSCIENCE AG (DE) | 2009-07-02 | — | — | WO | disclosed |
| WO-2009080182-A1 | HERBICIDAL COMPOUNDS BASED ON N-AZINYL-N'-PYRIDYLSULPHONYLUREAS | BAYER CROPSCIENCE AG (DE) | 2009-07-02 | — | — | WO | disclosed |
| EP-2072512-A1 | Herbicide compounds based on N-Azinyl-N'-pyridylsulfonyl-ureas | Bayer CropScience AG (DE) | 2009-06-24 | — | — | EP | disclosed |
| EP-2072512-A1 | Herbicide compounds based on N-Azinyl-N'-pyridylsulfonyl-ureas | Bayer CropScience AG (DE) | 2009-06-24 | — | — | EP | disclosed |
| US-20080182852-A1 | ANTHRANILAMIDE INHIBITORS OF AURORA KINASE | GLAXOSMITHKLINE LLC | 2008-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182852-A1 | ANTHRANILAMIDE INHIBITORS OF AURORA KINASE | AURKA, AURKC, AURKB | ALDH1A1 3182/4885CYP2C9 3987/4885MEN1 903/4885 |
| US-20100016318-A1 | ANTHRANILAMIDE INHIBITORS OF AURORA KINASE | AURKA, AURKC, AURKB | ALDH1A1 2849/4885CYP2C9 3669/4885MEN1 1046/4885 |
| US-20110028318-A1 | HERBICIDAL COMPOUNDS BASED ON N-AZINYL-N'-PYRIDYLSULPHONYLUREAS | DDT, AZI2, DNPH1 | ALDH1A1 133/4885CYP2C9 662/4885MEN1 4384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.