Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 7/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1204341 | 1.00 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1GAAHTT | |
| SCHEMBL13810647 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KDM4EL3MBTL1GAAHTT | |
| SCHEMBL1355343 | 0.74 | MAOA (0.46) | ALDH1A1KDM4EL3MBTL1GAAHTT | |
| SCHEMBL1355341 | 0.74 | MAOA (0.46) | ALDH1A1KDM4EL3MBTL1GAAHTT | |
| SCHEMBL29897004 | 0.74 | MAOA (0.46) | ALDH1A1KDM4EL3MBTL1GAAHTT | |
| SCHEMBL11173815 | 0.74 | L3MBTL1 (0.59) | ALDH1A1KDM4EL3MBTL1GAAHTT | |
| SCHEMBL1283654 | 0.72 | KDM4E (0.54) | ALDH1A1KDM4EL3MBTL1GAAHTT | |
| SCHEMBL1283651 | 0.72 | KDM4E (0.54) | ALDH1A1KDM4EL3MBTL1GAAHTT | |
| SCHEMBL31208201 | 0.72 | L3MBTL1 (0.65) | ALDH1A1KDM4EL3MBTL1GAAHTT | |
| SCHEMBL18497895 | 0.70 | KDM4E (0.37) | ALDH1A1KDM4EL3MBTL1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029393-B2 | Adenosine receptor ligands and uses thereof | KALDI PHARMA, SAS (FR) | 2015-05-12 | — | — | US | disclosed |
| EP-2391625-B1 | New adenosine receptor ligands and uses thereof | DOMAIN THERAPEUTICS (FR) | 2013-05-01 | — | — | EP | disclosed |
| US-20110288074-A1 | NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF | DOMAIN THERAPEUTICS (FR) | 2011-11-24 | — | — | US | disclosed |
| US-7893280-B2 | 2,4-disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2011-02-22 | — | — | US | disclosed |
| US-7893280-B2 | 2,4-disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2011-02-22 | — | — | US | disclosed |
| US-7893280-B2 | 2,4-disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2011-02-22 | — | — | US | disclosed |
| EP-2210891-A1 | New adenosine receptor ligands and uses thereof | Domain Therapeutics (FR) | 2010-07-28 | — | — | EP | disclosed |
| EP-1261607-B1 | 2,4-DISUBSTITUTED THIAZOLYL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-12 | — | — | EP | disclosed |
| US-20060211704-A1 | 2,4-Disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-21 | — | — | US | disclosed |
| US-7105550-B2 | 2,4-disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-12 | — | — | US | disclosed |
| US-20030203897-A1 | 2,4-Disubstituted thiazolyl derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211704-A1 | 2,4-Disubstituted thiazolyl derivatives | IL4, PTGER4, PTGER3 | ALDH1A1 1775/4885KDM4E 2474/4885L3MBTL1 3697/4885 |
| US-20030203897-A1 | 2,4-Disubstituted thiazolyl derivatives | IL4, PTGER4, PTGER1 | ALDH1A1 1094/4885KDM4E 2524/4885L3MBTL1 4275/4885 |
| US-20110288074-A1 | NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF | ADORA2A, ADORA1, ADORA2B | ALDH1A1 637/4885KDM4E 4203/4885L3MBTL1 3955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.