Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 6/20 | 0.41 |
| ▸ | FDPS | P14324 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12060356 | 0.92 | FDPS (0.46) | CHKAFDPSHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12048203 | 0.79 | FDPS (0.40) | FDPSGGPS1 | |
| SCHEMBL12048182 | 0.79 | FDPS (0.42) | FDPSGGPS1ATM | |
| SCHEMBL12048185 | 0.79 | GGPS1 (0.57) | FDPSGGPS1 | |
| SCHEMBL12048156 | 0.77 | GGPS1 (0.47) | FDPSGGPS1 | |
| SCHEMBL12048155 | 0.77 | FDPS (0.49) | FDPSHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL12048193 | 0.77 | FDPS (0.46) | FDPSGGPS1 | |
| SCHEMBL12048194 | 0.76 | GGPS1 (0.44) | FDPSGGPS1 | |
| SCHEMBL12048152 | 0.74 | GGPS1 (0.48) | FDPSGGPS1MAPT | |
| SCHEMBL11952615 | 0.72 | GGPS1 (0.52) | FDPSALDH1A1LMNAGGPS1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071573-B2 | Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, A BODY CORPORATE AND POLITIC OF THE STATE OF ILLINOIS (US) | 2011-12-06 | — | — | US | disclosed |
| US-7358361-B2 | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-04-15 | — | — | US | disclosed |