Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL231806 | 0.94 | DNM1 (0.43) | DNM1SMN1; SMN2MEN1KMT2ATP53 | |
| Bromide SCHEMBL232863 | 0.94 | DNM1 (0.43) | DNM1SMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL321584 | 0.93 | ALDH1A1 (0.44) | DNM1SMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL487054 | 0.93 | ALDH1A1 (0.44) | DNM1SMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL16731588 | 0.90 | DNM1 (0.51) | DNM1SMN1; SMN2MEN1KMT2ATP53 | |
| Bromide SCHEMBL6055899 | 0.89 | DNM1 (0.41) | DNM1SMN1; SMN2MEN1KMT2ATP53 | |
| Bromide SCHEMBL231675 | 0.89 | ALDH1A1 (0.48) | DNM1SMN1; SMN2MEN1KMT2ATP53 | |
| Bromide SCHEMBL231434 | 0.87 | DNM1 (0.59) | DNM1SMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL485968 | 0.87 | ALDH1A1 (0.50) | DNM1SMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL320399 | 0.86 | DNM1 (0.58) | DNM1SMN1; SMN2MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318263-B2 | Method for coating an object with a graft polymer layer | SURMODICS, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20110104392-A1 | GRAFTING APPARATUS AND METHOD OF USING | SURMODICS, INC. (US) | 2011-05-05 | — | — | US | disclosed |
| US-7883749-B2 | placing an object into a container, filling the container with a 1st solution of nonpolymeric grafting initiator, irradiating, removing the solution from the container, filling the container with a 2ns solution of polymerizable monomer or macromer, bubbling gas through the solution, irradiating; curable | SURMODICS, INC. (US) | 2011-02-08 | — | — | US | disclosed |
| US-20090176030-A1 | METHOD FOR COATING AN OBJECT WITH A GRAFT POLYMER LAYER | SURMODICS, INC. | 2009-07-09 | — | — | US | disclosed |
| EP-1594623-B1 | GRAFTING APPARTUS AND METHOD OF USING | SURMODICS INC (US) | 2007-04-11 | — | — | EP | disclosed |
| US-7041174-B2 | Grafting apparatus and method of using | SUNMODICS,INC. (US) | 2006-05-09 | — | — | US | disclosed |
| EP-1594623-A1 | GRAFTING APPARTUS AND METHOD OF USING | SurModics, Inc. (US) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004073885-A1 | GRAFTING APPARTUS AND METHOD OF USING | SURMODICS, INC. (US) | 2004-09-02 | — | — | WO | disclosed |
| US-20040161547-A1 | Grafting apparatus and method of using | SURMODICS, INC. | 2004-08-19 | — | — | US | disclosed |