Bromide

Bromide

SCHEMBL6055899

C[N+](C)(CC[N+](C)(Cc1ccc(C(=O)c2ccccc2)cc1)C[N+](C)(CC[N+](C)(C)Cc1ccc(C(=O)c2ccccc2)cc1)Cc1ccc(C(=O)c2ccccc2)cc1)Cc1ccc(C(=O)c2ccccc2)cc1.[Br-].[Br-].[Br-].[Br-]

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.39
DNM1 Q05193 2/20 0.41
ALDH1A1 P00352 5/20 0.40
HTT P42858 4/20 0.40
SMN1; SMN2 Q16637 3/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
ATM Q13315 2/20 0.40
SRD5A2 P31213 3/20 0.40
HPGD P15428 3/20 0.39
RAB9A P51151 3/20 0.38
NPC1 O15118 1/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
TP53 P04637 1/20 0.38
MAPK1 P28482 1/20 0.38
ELANE P08246 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL231806 0.94 DNM1 (0.43) DNM1ALDH1A1HTTSMN1; SMN2L3MBTL1
Bromide SCHEMBL232863 0.94 DNM1 (0.43) DNM1ALDH1A1HTTSMN1; SMN2L3MBTL1
SCHEMBL487054 0.93 ALDH1A1 (0.44) DNM1ALDH1A1HTTSMN1; SMN2L3MBTL1
SCHEMBL321584 0.93 ALDH1A1 (0.44) DNM1ALDH1A1HTTSMN1; SMN2L3MBTL1
Bromide SCHEMBL231675 0.91 ALDH1A1 (0.48) DNM1ALDH1A1HTTSMN1; SMN2L3MBTL1
SCHEMBL485968 0.89 ALDH1A1 (0.50) DNM1ALDH1A1HTTSMN1; SMN2L3MBTL1
Bromide SCHEMBL1205091 0.89 DNM1 (0.46) DNM1ALDH1A1HTTSMN1; SMN2L3MBTL1
Bromide SCHEMBL29669478 0.84 DNM1 (0.51) DNM1ALDH1A1HTTSMN1; SMN2L3MBTL1
Bromide SCHEMBL231434 0.84 DNM1 (0.59) DNM1ALDH1A1HTTSMN1; SMN2L3MBTL1
SCHEMBL16731588 0.83 DNM1 (0.51) DNM1ALDH1A1HTTSMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1465740-A4 REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES SURMODICS INC (US) 2006-06-07 EP claimed
JP-2005514192-A 2005-05-19 JP claimed
EP-1465740-A1 REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES SurModics, Inc. (US) 2004-10-13 EP claimed
WO-2003055611-A1 REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES SURMODICS, INC. (US) 2003-07-10 WO claimed