Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.60 |
| ▸ | PLAU | P00749 | 1/20 | 0.59 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.59 |
| ▸ | GALK1 | P51570 | 1/20 | 0.58 |
| ▸ | CASP6 | P55212 | 1/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | PLEC | Q15149 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL155094 | 0.88 | PGR (0.72) | NR1H4RAB9ALMNAHPGDNPC1 | |
| SCHEMBL17084712 | 0.88 | PGR (0.72) | NR1H4RAB9ALMNAHPGDNPC1 | |
| SCHEMBL22543145 | 0.86 | NR1H4 (0.78) | NR1H4RAB9AMAPTLMNAHPGD | |
| SCHEMBL13211973 | 0.85 | NR1H4 (0.68) | NR1H4RAB9AMAPTLMNAHPGD | |
| SCHEMBL22542833 | 0.85 | GALK1 (0.76) | NR1H4RAB9AMAPTLMNAHPGD | |
| SCHEMBL13779847 | 0.84 | TRPV1 (0.66) | RAB9ANPC1TRPV1KMT2AALDH1A1 | |
| SCHEMBL10162575 | 0.83 | TRPV1 (0.71) | NR1H4RAB9AMAPTHPGDNPC1 | |
| SCHEMBL12201930 | 0.83 | KCNK9 (0.74) | NR1H4RAB9AMAPTLMNAHPSE | |
| SCHEMBL19491393 | 0.82 | SIRT1 (0.72) | RAB9AMAPTHPSENPC1TRPV1 | |
| SCHEMBL95395 | 0.82 | NR1H4 (0.68) | NR1H4RAB9AMAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357699-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-20110319390-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2011-12-29 | — | — | US | disclosed |
| US-8034943-B2 | 6-aminoisoquinoline compounds | AERIE PHARMACEUTICALS, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-20110183965-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | AERIE PHARMACEUTICALS, INC. (US) | 2011-07-28 | — | — | US | disclosed |
| US-20100137364-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| US-20080167340-A1 | 6-Aminoisoquinoline Compounds | AERIE PHARMACEUTICALS, INC. (US) | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137364-A1 | 6-Aminoisoquinoline Compounds | COQ8A, PGC, AGK | NR1H4 1330/4885RAB9A 568/4885MAPT 1151/4885 |
| US-20080167340-A1 | 6-Aminoisoquinoline Compounds | COQ8A, PGC, AGK | NR1H4 1330/4885RAB9A 568/4885MAPT 1151/4885 |
| US-20110183965-A1 | 6-AMINOISOQUINOLINE COMPOUNDS | COQ8A, PGC, AGK | NR1H4 1330/4885RAB9A 568/4885MAPT 1151/4885 |
| US-20110319390-A1 | 6-Aminoisoquinoline Compounds | COQ8A, PGC, AGK | NR1H4 1330/4885RAB9A 568/4885MAPT 1151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.