Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.31 |
| ▸ | CKS1B | P61024 | 1/20 | 0.31 |
| ▸ | SKP1 | P63208 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 7/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470798 | 0.90 | DPP4 (0.32) | DPP4DPP7DPP8DPP9CYP2D6 | |
| SCHEMBL461775 | 0.89 | OPRK1 (0.31) | NR1H2RET | |
| SCHEMBL12064592 | 0.88 | NR1H2 (0.31) | DPP4DPP7DPP8DPP9CYP2D6 | |
| SCHEMBL470535 | 0.88 | NR1H2 (0.33) | NR1H2ACACBEIF2AK4CKS1BSKP1 | |
| SCHEMBL463066 | 0.87 | NR1H2 (0.33) | NR1H2EIF2AK4CKS1BSKP1SKP2 | |
| SCHEMBL462819 | 0.86 | NTRK1 (0.34) | DPP4DPP7DPP8DPP9NR1H2 | |
| SCHEMBL470523 | 0.85 | NTRK1 (0.35) | KCNH2NR1H2EIF2AK4CKS1BSKP1 | |
| SCHEMBL12064814 | 0.84 | NR1H2 (0.33) | KCNH2NR1H2ACACBEIF2AK4CKS1B | |
| SCHEMBL12064983 | 0.84 | GPR119 (0.36) | KCNH2NR1H2GRM4 | |
| SCHEMBL470580 | 0.84 | NR1H2 (0.33) | NR1H2ACACBEIF2AK4CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |