Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 4/20 | 0.50 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.46 |
| ▸ | PDXK | O00764 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.46 |
| ▸ | STK16 | O75716 | 1/20 | 0.46 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.46 |
| ▸ | LATS1 | O95835 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14983452 | 0.91 | PIK3CG (0.56) | PIK3CGJAK1TYK2PIK3CDPIK3C2B | |
| SCHEMBL12067539 | 0.82 | DHFR (0.56) | PIK3CGJAK1TYK2PIK3CDPIK3C2B | |
| SCHEMBL14983451 | 0.80 | PIK3CG (0.76) | PIK3CGJAK1TYK2PIK3CDPIK3C2B | |
| SCHEMBL14983465 | 0.80 | PIK3CG (0.47) | PIK3CGPIK3CDGAKABL1EGFR | |
| SCHEMBL14325117 | 0.77 | PIK3CG (0.78) | PIK3CGJAK1TYK2PIK3CDPIK3C2B | |
| SCHEMBL14983450 | 0.76 | PIK3CG (0.76) | PIK3CGJAK1TYK2PIK3CDPIK3C2B | |
| SCHEMBL12198179 | 0.74 | PIK3CG (0.78) | PIK3CGJAK1TYK2PIK3CDPIK3C2B | |
| SCHEMBL14983458 | 0.74 | ADORA1 (0.55) | JAK1TYK2L3MBTL1KDM4EHSD17B10 | |
| SCHEMBL12954844 | 0.73 | PIK3CG (0.70) | PIK3CGJAK1TYK2PIK3CDPIK3C2B | |
| SCHEMBL4411134 | 0.73 | NOS1 (0.55) | PIK3CGJAK1TYK2GAKPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160083388-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | TRT PHARMA INC. (CA) | 2016-03-24 | — | — | US | disclosed |
| US-20160083388-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | TRT PHARMA INC. (CA) | 2016-03-24 | — | — | US | disclosed |
| US-9139592-B2 | Modulators of Nrf2 and uses thereof | TRT PHARMA INC. (CA) | 2015-09-22 | — | — | US | disclosed |
| US-9139592-B2 | Modulators of Nrf2 and uses thereof | TRT PHARMA INC. (CA) | 2015-09-22 | — | — | US | disclosed |
| US-20130137694-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | TRT PHARMA INC. (CA) | 2013-05-30 | — | — | US | disclosed |
| US-20130137694-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | TRT PHARMA INC. (CA) | 2013-05-30 | — | — | US | disclosed |
| WO-2011156889-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | TRT PHARMA INC. (CA) | 2011-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137694-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | KEAP1, TXNRD1, NFE2L2 | PIK3CG 3893/4885JAK1 3676/4885TYK2 3389/4885 |
| US-20160083388-A1 | NOVEL MODULATORS OF NRF2 AND USES THEREOF | KEAP1, TXNRD1, NFE2L2 | PIK3CG 3893/4885JAK1 3676/4885TYK2 3389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.