Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 2/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 3/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6838 | 0.91 | L3MBTL1 (0.40) | TSHRL3MBTL1TDP1ATMALDH1A1 | |
| SCHEMBL7480 | 0.87 | LPAR1 (0.50) | TSHRL3MBTL1TDP1ATMALDH1A1 | |
| SCHEMBL6888 | 0.87 | FFAR1 (0.47) | TSHRSMN1; SMN2MAPK1LPAR1LPAR3 | |
| SCHEMBL7241 | 0.85 | LIPG (0.44) | TSHRRAB9AFAAH | |
| SCHEMBL6689 | 0.84 | LIPG (0.43) | TSHRL3MBTL1TDP1ATMBRD4 | |
| SCHEMBL7249 | 0.84 | PPARG (0.51) | TSHRL3MBTL1TDP1ATMBRD4 | |
| SCHEMBL6800 | 0.84 | RAB9A (0.45) | TSHRL3MBTL1TDP1ATMALDH1A1 | |
| SCHEMBL1596 | 0.84 | LPAR1 (0.52) | TSHRL3MBTL1TDP1ATMALDH1A1 | |
| SCHEMBL18597722 | 0.84 | LPAR1 (0.37) | TSHRL3MBTL1TDP1ATMALDH1A1 | |
| SCHEMBL6548 | 0.83 | PTGER4 (0.47) | TSHRLPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |