Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 4/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | PLG | P00747 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.40 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177564 | 0.80 | ABHD6 (0.50) | TMEM97SIGMAR1ESR2MAP3K5ABHD6 | |
| SCHEMBL30055666 | 0.80 | TMEM97 (0.47) | TMEM97SIGMAR1ESR2LMNAABHD6 | |
| SCHEMBL120960 | 0.78 | ESR2 (0.45) | TMEM97SIGMAR1ESR2ABHD6 | |
| SCHEMBL20570860 | 0.78 | MAP3K5 (0.51) | TMEM97SIGMAR1MAP3K5ERN1F10 | |
| SCHEMBL29407529 | 0.78 | ESR2 (0.70) | TMEM97SIGMAR1ESR2MAPK1RAB9A | |
| SCHEMBL168265 | 0.78 | ESR2 (0.70) | TMEM97SIGMAR1ESR2MAPK1RAB9A | |
| SCHEMBL16634622 | 0.77 | NAMPT (0.49) | TMEM97SIGMAR1ESR2RAB9A | |
| SCHEMBL20571487 | 0.77 | MAP3K5 (0.51) | TMEM97SIGMAR1MAP3K5ERN1F10 | |
| SCHEMBL7850845 | 0.76 | NR1H2 (0.49) | TMEM97SIGMAR1ESR2RAB9AABHD6 | |
| SCHEMBL20571794 | 0.75 | MAP3K5 (0.53) | TMEM97SIGMAR1MAP3K5ERN1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424861-A1 | INDOLE-2-CARBOXAMIDE DERIVATIVE | MSD K.K. (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20120035155-A1 | INDOLE-2-CARBOXAMIDE DEIVATIVE | MSD K.K. (JP) | 2012-02-09 | — | — | US | disclosed |
| WO-2010126164-A1 | INDOLE-2-CARBOXAMIDE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035155-A1 | INDOLE-2-CARBOXAMIDE DEIVATIVE | HTR1F, HTR3C, HTR6 | TMEM97 497/4885SIGMAR1 82/4885ESR2 1065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.