Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | NAMPT | P43490 | 7/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29407529 | 0.80 | ESR2 (0.70) | ESR2TMEM97SIGMAR1NAMPTABHD6 | |
| SCHEMBL2177564 | 0.80 | ABHD6 (0.50) | ESR2TMEM97SIGMAR1NAMPTABHD6 | |
| SCHEMBL168265 | 0.80 | ESR2 (0.70) | ESR2TMEM97SIGMAR1NAMPTABHD6 | |
| SCHEMBL7850845 | 0.78 | NR1H2 (0.49) | ESR2TMEM97SIGMAR1NAMPTABHD6 | |
| SCHEMBL120959 | 0.78 | TMEM97 (0.50) | ESR2TMEM97SIGMAR1ABHD6 | |
| SCHEMBL16634622 | 0.77 | NAMPT (0.49) | ESR2TMEM97SIGMAR1NAMPTESR1 | |
| SCHEMBL30055666 | 0.77 | TMEM97 (0.47) | ESR2TMEM97SIGMAR1NAMPTABHD6 | |
| SCHEMBL2178804 | 0.75 | ABHD6 (0.49) | ESR2TMEM97SIGMAR1NAMPTABHD6 | |
| SCHEMBL29407557 | 0.75 | NR1H2 (0.69) | ESR2TMEM97SIGMAR1NAMPTABHD6 | |
| SCHEMBL1285596 | 0.75 | NR1H2 (0.69) | ESR2TMEM97SIGMAR1NAMPTABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424861-A1 | INDOLE-2-CARBOXAMIDE DERIVATIVE | MSD K.K. (JP) | 2012-03-07 | — | — | EP | disclosed |
| US-20120035155-A1 | INDOLE-2-CARBOXAMIDE DEIVATIVE | MSD K.K. (JP) | 2012-02-09 | — | — | US | disclosed |
| WO-2010126164-A1 | INDOLE-2-CARBOXAMIDE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035155-A1 | INDOLE-2-CARBOXAMIDE DEIVATIVE | HTR1F, HTR3C, HTR6 | ESR2 1065/4885TMEM97 497/4885SIGMAR1 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.