Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.41 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19072757 | 1.00 | L3MBTL1 (0.43) | L3MBTL1KCNH2OPRM1OPRD1MRGPRX2 | |
| SCHEMBL12099374 | 1.00 | L3MBTL1 (0.43) | L3MBTL1KCNH2OPRM1OPRD1MRGPRX2 | |
| SCHEMBL12099371 | 1.00 | L3MBTL1 (0.43) | L3MBTL1KCNH2OPRM1OPRD1MRGPRX2 | |
| SCHEMBL2009362 | 0.76 | L3MBTL1 (0.50) | L3MBTL1TP53CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL16751400 | 0.73 | KCNH2 (0.45) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 | |
| SCHEMBL2009360 | 0.70 | SLC22A1 (0.56) | L3MBTL1OPRM1TP53CYP3A4CYP2C19 | |
| SCHEMBL12163005 | 0.70 | SLC22A1 (0.56) | L3MBTL1OPRM1TP53CYP3A4CYP2C19 | |
| SCHEMBL2551526 | 0.70 | OPRM1 (0.46) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 | |
| SCHEMBL755809 | 0.70 | KCNH2 (0.46) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 | |
| SCHEMBL14516176 | 0.70 | KCNH2 (0.46) | KCNH2OPRM1OPRD1MRGPRX2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507203-B1 | NEW PROCESS FOR THE PREPARATION OF TAPENTADOL AND INTERMEDIATES THEREOF | EUTICALS SPA (IT) | 2017-07-05 | — | — | EP | disclosed |
| US-8729308-B2 | Process for the preparation of tapentadol and intermediates thereof | EUTICALS S.P.A. (IT) | 2014-05-20 | — | — | US | disclosed |
| US-20120232306-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL AND INTERMEDIATES THEREOF | EUTICALS S.P.A. (IT) | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232306-A1 | PROCESS FOR THE PREPARATION OF TAPENTADOL AND INTERMEDIATES THEREOF | OPRK1, OPRD1, OPRL1 | L3MBTL1 3801/4885KCNH2 2475/4885OPRM1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.