Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.83 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.63 |
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | NOS2 | P35228 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31033181 | 0.91 | SIGMAR1 (1.00) | SIGMAR1TMEM97 | |
| SCHEMBL12359956 | 0.84 | SIGMAR1 (0.87) | SIGMAR1TMEM97 | |
| SCHEMBL12124710 | 0.79 | SIGMAR1 (0.77) | SIGMAR1 | |
| SCHEMBL12124425 | 0.79 | TMEM97 (0.66) | SIGMAR1TMEM97NOS3NOS1NOS2 | |
| SCHEMBL6408326 | 0.78 | TMEM97 (0.72) | SIGMAR1TMEM97NOS3NOS1NOS2 | |
| SCHEMBL25139666 | 0.77 | SIGMAR1 (0.52) | SIGMAR1 | |
| SCHEMBL12124484 | 0.74 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL6408019 | 0.74 | TMEM97 (0.66) | SIGMAR1TMEM97NOS3NOS1NOS2 | |
| SCHEMBL12124423 | 0.74 | SIGMAR1 (0.71) | SIGMAR1TMEM97 | |
| SCHEMBL12124543 | 0.70 | SLC6A2 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3102204-B1 | HIGHLY SELECTIVE SIGMA 1 RECEPTOR LIGANDS AND RADIOLIGANDS AS PROBES IN NOCICEPTIVE PROCESSING AND THE PATHOPHYSIOLOGICAL STUDY OF MEMORY DEFICITS AND COGNITIVE DISORDERS | THE UNIV OF MISSISSIPPI (US) | 2021-05-05 | — | — | EP | disclosed |
| US-9724435-B2 | Highly selective sigma receptor ligands and radioligands as probes in nociceptive processing and the pathphysiological study of memory deficits and cognitive disorders | THE UNIVERSITY OF MISSISSIPPI (US) | 2017-08-08 | — | — | US | disclosed |
| US-9724435-B2 | Highly selective sigma receptor ligands and radioligands as probes in nociceptive processing and the pathphysiological study of memory deficits and cognitive disorders | THE UNIVERSITY OF MISSISSIPPI (US) | 2017-08-08 | — | — | US | disclosed |
| US-9604926-B2 | Highly selective sigma receptor radioligands | THE UNIVERSITY OF MISSISSIPPI (US) | 2017-03-28 | — | — | US | disclosed |
| US-9604926-B2 | Highly selective sigma receptor radioligands | THE UNIVERSITY OF MISSISSIPPI (US) | 2017-03-28 | — | — | US | disclosed |
| WO-2015134545-A2 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS AND RADIOLIGANDS AS PROBES IN NOCICEPTIVE PROCESSING AND THE PATHPHYSIOLOGICAL STUDY OF MEMORY DEFICITS AND CONITIVE DISORDERS | THE UNIVERSITY OF MISSISSIPPI (US) | 2015-09-11 | — | — | WO | disclosed |
| US-20140328755-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS AND RADIOLIGANDS AS PROBES IN NOCICEPTIVE PROCESSING AND THE PATHPHYSIOLOGICAL STUDY OF MEMORY DEFICITS AND COGNITIVE DISORDERS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2014-11-06 | — | — | US | disclosed |
| US-20140328755-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS AND RADIOLIGANDS AS PROBES IN NOCICEPTIVE PROCESSING AND THE PATHPHYSIOLOGICAL STUDY OF MEMORY DEFICITS AND COGNITIVE DISORDERS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2014-11-06 | — | — | US | disclosed |
| US-20140315919-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | UNIV MISSISSIPPI (US) | 2014-10-23 | — | — | US | disclosed |
| US-20140315919-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | UNIV MISSISSIPPI (US) | 2014-10-23 | — | — | US | disclosed |
| US-8809381-B2 | Highly selective sigma receptor ligands | THE UNIVERSITY OF MISSISSIPPI (US) | 2014-08-19 | — | — | US | disclosed |
| US-8809381-B2 | Highly selective sigma receptor ligands | THE UNIVERSITY OF MISSISSIPPI (US) | 2014-08-19 | — | — | US | disclosed |
| US-20110280804-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR RADIOLIGANDS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-11-17 | — | — | US | disclosed |
| US-20110280804-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR RADIOLIGANDS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2011-11-17 | — | — | US | disclosed |
| US-20110195955-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | L'UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2011-08-11 | — | — | US | disclosed |
| US-20110195955-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | L'UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) | 2011-08-11 | — | — | US | disclosed |
| US-20100329978-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | UNIVERSITY OF MISSISSIPPI (US) | 2010-12-30 | — | — | US | disclosed |
| US-20100329978-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | UNIVERSITY OF MISSISSIPPI (US) | 2010-12-30 | — | — | US | disclosed |
| WO-2009026227-A2 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | THE UNIVERSITY OF MISSISSIPPI (US) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100329978-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | SIGMAR1, OPRL1, CNR1 | SIGMAR1 1/4885TMEM97 8/4885NOS3 542/4885 |
| US-20140315919-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | SIGMAR1, OPRD1, OPRM1 | SIGMAR1 1/4885TMEM97 9/4885NOS3 428/4885 |
| US-20110195955-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS | SIGMAR1, OPRD1, OPRM1 | SIGMAR1 1/4885TMEM97 9/4885NOS3 428/4885 |
| US-20140328755-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR LIGANDS AND RADIOLIGANDS AS PROBES IN NOCICEPTIVE PROCESSING AND THE PATHPHYSIOLOGICAL STUDY OF MEMORY DEFICITS AND COGNITIVE DISORDERS | SIGMAR1, OPRL1, OPRK1 | SIGMAR1 1/4885TMEM97 6/4885NOS3 1701/4885 |
| US-20110280804-A1 | HIGHLY SELECTIVE SIGMA RECEPTOR RADIOLIGANDS | SIGMAR1, MSR1, TMEM97 | SIGMAR1 1/4885TMEM97 3/4885NOS3 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.