Beta-2'-C-Methyl-7-Deaza-Adenosine

Beta-2'-C-Methyl-7-Deaza-Adenosine

SCHEMBL12149452

C[C@]1(O)C(O)[C@@H](CO)O[C@H]1n1ccc2c(N)ncnc21

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ ADORA2A P29274 4/20 0.67
▸ PRMT5 O14744 12/20 0.57
▸ WDR77 Q9BQA1 12/20 0.57
▸ ADK P55263 1/20 0.53
▸ ADORA3 P0DMS8 4/20 0.52
▸ ADA P00813 1/20 0.48
▸ ADORA2B P29275 1/20 0.48
▸ ADORA1 P30542 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Beta-2'-C-Methyl-7-Deaza-Adenosine SCHEMBL14081715 1.00 ADORA2A (0.67) ADORA2APRMT5WDR77ADKADORA3
Beta-2'-C-Methyl-7-Deaza-Adenosine SCHEMBL12150774 1.00 ADORA2A (0.67) ADORA2APRMT5WDR77ADKADORA3
Beta-2'-C-Methyl-7-Deaza-Adenosine SCHEMBL15093204 1.00 ADORA2A (0.67) ADORA2APRMT5WDR77ADKADORA3
Beta-2'-C-Methyl-7-Deaza-Adenosine SCHEMBL18661674 1.00 ADORA2A (0.67) ADORA2APRMT5WDR77ADKADORA3
Beta-2'-C-Methyl-7-Deaza-Adenosine SCHEMBL14628542 1.00 ADORA2A (0.67) ADORA2APRMT5WDR77ADKADORA3
Beta-2'-C-Methyl-7-Deaza-Adenosine SCHEMBL6422519 1.00 ADORA2A (0.67) ADORA2APRMT5WDR77ADKADORA3
Beta-2'-C-Methyl-7-Deaza-Adenosine SCHEMBL733423 1.00 ADORA2A (0.67) ADORA2APRMT5WDR77ADKADORA3
Beta-2'-C-Methyl-7-Deaza-Adenosine SCHEMBL13772636 1.00 ADORA2A (0.67) ADORA2APRMT5WDR77ADKADORA3
Beta-2'-C-Methyl-7-Deaza-Adenosine SCHEMBL14628545 1.00 ADORA2A (0.67) ADORA2APRMT5WDR77ADKADORA3
Beta-2'-C-Methyl-7-Deaza-Adenosine SCHEMBL14640071 1.00 ADORA2A (0.67) ADORA2APRMT5WDR77ADKADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9828409-B2 Bridged-cyclo-ProTides as prodrugs of therapeutic nucleosides and nucleotides ZHONG MINGHONG (US) 2017-11-28 — — US disclosed
EP-2552203-B1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS IDENIX PHARMACEUTICALS LLC (US) 2017-03-22 — — EP disclosed
EP-2755983-B1 SUBSTITUTED CARBONYLOXYMETHYLPHOSPHORAMIDATE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS IDENIX PHARMACEUTICALS LLC (US) 2017-03-15 — — EP disclosed
US-9403863-B2 Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections IDENIX PHARMACEUTICALS LLC (US) 2016-08-02 — — US disclosed
US-9403863-B2 Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections IDENIX PHARMACEUTICALS LLC (US) 2016-08-02 — — US disclosed
US-9249173-B2 Compounds and pharmaceutical compositions for the treatment of viral infections IDENIX PHARMACEUTICALS, LLC (US) 2016-02-02 — — US disclosed
US-9249173-B2 Compounds and pharmaceutical compositions for the treatment of viral infections IDENIX PHARMACEUTICALS, LLC (US) 2016-02-02 — — US disclosed
US-9243025-B2 Compounds and pharmaceutical compositions for the treatment of viral infections IDENIX PHARMACEUTICALS, LLC (US) 2016-01-26 — — US disclosed
US-9243025-B2 Compounds and pharmaceutical compositions for the treatment of viral infections IDENIX PHARMACEUTICALS, LLC (US) 2016-01-26 — — US disclosed
US-9186369-B2 Purine nucleoside analogues for treating flaviviridae including hepatitis C IDENIX PHARMACEUTICALS, LLC (US) 2015-11-17 — — US disclosed
US-20120251487-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS IDENIX PHARMACEUTICALS LLC 2012-10-04 — — US disclosed
US-20110286962-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS IDENIX PHARMACEUTICALS, INC. 2011-11-24 — — US disclosed
US-20110286962-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS IDENIX PHARMACEUTICALS, INC. 2011-11-24 — — US disclosed
US-20110243886-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS SURLERAUX DOMINIQUE 2011-10-06 — — US disclosed
US-7951789-B2 Compounds and pharmaceutical compositions for the treatment of viral infections IDENIX PHARMACEUTICALS, INC. (US) 2011-05-31 — — US disclosed
US-7951789-B2 Compounds and pharmaceutical compositions for the treatment of viral infections IDENIX PHARMACEUTICALS, INC. (US) 2011-05-31 — — US disclosed
US-20080286230-A1 Compounds and pharmaceutical compositions for the treatment of viral infections IDENIX PHARMACEUTICALS, INC. 2008-11-20 — — US disclosed
US-20080286230-A1 Compounds and pharmaceutical compositions for the treatment of viral infections IDENIX PHARMACEUTICALS, INC. 2008-11-20 — — US disclosed
US-7163929-B2 Methods and compositions for treating flaviviruses and pestiviruses IDENIX PHARMACEUTICALS, INC. (US) 2007-01-16 — — US disclosed
US-7163929-B2 Methods and compositions for treating flaviviruses and pestiviruses IDENIX PHARMACEUTICALS, INC. (US) 2007-01-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080286230-A1 Compounds and pharmaceutical compositions for the treatment of viral infections HAVCR2, PYGL, GYS2 ADORA2A 1132/4885PRMT5 3572/4885WDR77 3471/4885
US-20110243886-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS HAVCR2, PYGL, EIF2AK2 ADORA2A 608/4885PRMT5 1285/4885WDR77 1902/4885
US-20120251487-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS HAVCR2, PYGL, EIF2AK2 ADORA2A 608/4885PRMT5 1285/4885WDR77 1902/4885
US-20110286962-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS HAVCR2, PYGL, GYS2 ADORA2A 1132/4885PRMT5 3572/4885WDR77 3471/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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