SCHEMBL12154697

SCHEMBL12154697

C=CC(=O)OCCOc1ccc(Cc2ccc(-c3ccc(C#N)cc3)cc2)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.55
MMP2 P08253 8/20 0.52
MMP3 P08254 6/20 0.49
MMP1 P03956 1/20 0.49
MMP9 P14780 1/20 0.49
MMP13 P45452 1/20 0.49
MAPT P10636 2/20 0.47
ALDH1A1 P00352 1/20 0.47
HDAC1 Q13547 1/20 0.46
HDAC2 Q92769 1/20 0.46
POLB P06746 1/20 0.44
ABCB1 P08183 1/20 0.43
HPGD P15428 1/20 0.43
ABCG2 Q9UNQ0 1/20 0.43
HRH2 P25021 2/20 0.42
HRH1 P35367 2/20 0.42
HRH3 Q9Y5N1 2/20 0.42
SAE1 Q9UBE0 1/20 0.42
UBA2 Q9UBT2 1/20 0.42
PPARD Q03181 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL471107 0.94 THRB (0.61) THRBMMP2MMP3MMP1MMP9
SCHEMBL25123497 0.90 THRB (0.57) THRBMMP2MMP3MMP1MMP9
SCHEMBL7587630 0.90 THRB (0.57) THRBMMP2MMP3MMP1MMP9
SCHEMBL9880801 0.90 THRB (0.57) THRBMMP2MMP3MMP1MMP9
SCHEMBL12348073 0.89 THRB (0.67) THRBMMP2MMP3MMP1MMP9
SCHEMBL13427412 0.89 THRB (0.49) THRBMMP2MMP3MMP1MMP9
SCHEMBL14562517 0.87 THRB (0.49) THRBMMP2MMP3MMP1MMP9
SCHEMBL4331061 0.87 MMP2 (0.57) THRBMMP2MMP3MMP1MMP9
SCHEMBL5961806 0.87 MMP3 (0.58) THRBMMP2MMP3MMP1MMP9
SCHEMBL331673 0.87 THRB (0.71) THRBALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8049850-B2 Liquid crystal display device, optical compensatory sheet, and polarizer and liquid crystal display device employing the same FUJIFILM CORPORATION (JP) 2011-11-01 US disclosed
US-20090122243-A1 Liquid Crystal Display Device, Optical Compensatory Sheet, and Polarizer and Liquid Crystal Display Device Employing the Same FUJIFILM CORPORATION (JP) 2009-05-14 US disclosed
US-7317498-B2 Viewing angle magnification liquid crystal display unit NITTO DENKO CORPORATION (JP) 2008-01-08 US disclosed