Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | CASP3 | P42574 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.66 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.66 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
| ▸ | DUSP22 | Q9NRW4 | 4/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12177278 | 0.87 | NPC1 (0.57) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL12177689 | 0.85 | AKR1B1 (0.60) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL12177369 | 0.84 | LMNA (0.62) | POLBTDP1L3MBTL1 | |
| SCHEMBL12177341 | 0.81 | AKR1B1 (0.58) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL12177382 | 0.80 | POLB (0.66) | NPC1RAB9APOLBPKMAPEX1 | |
| SCHEMBL12177730 | 0.78 | KDM4E (0.50) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL6184899 | 0.78 | PIK3CG (0.67) | RAB9APOLBTDP1AKR1B1 | |
| SCHEMBL6184897 | 0.78 | PIK3CG (0.67) | RAB9APOLBTDP1AKR1B1 | |
| SCHEMBL12177140 | 0.76 | CYP1A2 (0.53) | NPC1TDP1AKR1B1 | |
| SCHEMBL7464201 | 0.76 | CISD1 (0.71) | NPC1CASP3RAB9ASENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011135303-A2 | UBIQUITINATION MODULATORS | ITI SCOTLAND LIMITED (GB) | 2011-11-03 | — | — | WO | disclosed |